Browse our latest Immunology and Inflammation articles

Trans genetic variation in TdT and Artemis loci impacts V(D)J recombination probabilities.

A phase transition of TIR-1/SARM1 induced by either pathogen or non-pathogen stress potentiates its intrinsic NADase activity, which activates the p38 PMK-1 signaling cascade to induce protective immune defenses in Caenorhabditis elegans intestinal epithelial cells.

Inflammatory responses mediated by gasdermins are important for adequate fracture healing.

Non-neutralizing antibodies to the SARS-CoV-2 spike protein’s S2 domain that also recognize widely circulating endemic coronavirus strains are rapidly boosted by natural infection but not vaccination with stabilized spike-based vaccines.

A dual role of immune cells was found in ALS prognosis, where neutrophils and monocytes primarily reflect functional status whereas NK cells and different T lymphocyte populations act as prognostic markers for survival.

SPRRs are bactericidal proteins, stimulated in the sebaceous gland by lipopolysaccharide, that defend the host against infection through bacterial membrane binding and disruption.

Deletion of Alzheimer’s disease risk gene TREM2 augments sensitivity to the purinergic agonist ADP, leading to increased Ca²⁺ influx and reduced directional migration in human induced pluripotent stem cell-derived microglia.

Phosphorylation of the phosphatase SHP-1 by PKC-θ in natural killer (NK) cells induces SHP-1 inhibition, revealing a novel molecular pathway that sustains NK cell activation threshold.

Cellular, genetic, and biochemical assays shows that the application of a specific type of currents in mouse tendons induces an inflammatory response that favors the regeneration of the tissue, being a treatment for chronic tendinopathy lesions.

The prolyl hydroxylase domain 2 regulates the Treg development and function in a hypoxia-inducible factor 2α-dependent manner.