Heparan sulfate-RAGE interaction is essential for normal function of RAGE in osteoclastogenesis and drug-induced liver damage, which can be targeted to curb RAGE activation as a new opportunity.
RNA m6A level is dually regulated during RV infection and development, METTL3 deficiency in IECs results in increased resistance to rotaviral infection through reduced m6A modificaitons on Irf7.
Self-reactive CD4+ thymocytes have a broad impact on the composition of medullary thymic epithelial cell (mTEC) subsets by acting upstream of Aire+ mTECs, which conditions the induction of T-cell tolerance.
Charlotte E Davies, Jessica E Thomas ... Christopher J Coates
Neither the presence nor the intensity of Hematodinium sp. parasitisation drives co-infection occurrence, severity, or diversity in the ecologically ubiquitous shore crab, Carcinus maenas.
Jacob A Van Winkle, Stefan T Peterson ... Timothy J Nice
The enteric bacterial microbiota stimulates a highly localized interferon-lambda signal within the intestinal epithelium that protects against murine rotavirus infection.
Live imaging of the duel of an NK cell versus a metastatic cancer cell on pulmonary epithelial cells reveals a novel survival tactics adopted by cancer cells.
A multiomics, systems biology approach was used to define the metabolic and signaling programs that drive the fate and function of pancreatic tumor-associated macrophages.
