A novel binning approach provides evidence for super-functional T cells with high activation potential and which exhibit Tfh-like functionalities and can help B cells.
Targeting the differentiation regulators and/or AMPs of keratinocytes, rather than targeting immune cells, may be an alternative approach for topical anti-psoriatic treatment, an area with high need for new drugs.
HLA class I-disease associations have been studied for decades; a new approach for investigating the underlying mechanism can overcome past problems with interpretation and help to understand the etiology of human diseases.
Circulating myeloid cells invade the brain during pancreatic cancer, where they accumulate at a unique central nervous system interface and drive anorexia and muscle catabolism.
SKAP2 is critical for hematopoietic cell protection against Klebsiella infection in mouse lungs, for full phosphorylation of Src Family Kinases, Syk, and Pyk2, and for Klebsiella-induced reactive oxygen species production.
Sudhir Gopal Tattikota, Bumsik Cho ... Norbert Perrimon
Single-cell RNA sequencing of Drosophila hemocytes in blood distinguishes various states within known blood cell types and implicates a novel role for fibroblast growth factor receptor signaling in inter-hemocyte crosstalk.
A library of the paired peptide/HLA multimers and artificial APCs allows for construction of a large database of class I-restricted peptides and cognate tumor-reactive TCR genes at an unprecedented scale.
