Browse our latest Immunology and Inflammation articles

Page 76 of 125
    1. Immunology and Inflammation

    Seroconversion stages COVID19 into distinct pathophysiological states

    Matthew D Galbraith, Kohl T Kinning ... Joaquín M Espinosa
    Stratification of COVID19 patients using quantitative metrics of seroconversion reveals distinct pathophysiological stages after SARS-CoV-2 infection, including key differences in immune cell types, inflammatory makers, and markers of organ function.
    1. Immunology and Inflammation
    2. Neuroscience

    Microglial trogocytosis and the complement system regulate axonal pruning in vivo

    Tony KY Lim, Edward S Ruthazer
    In vivo time lapse imaging reveals that microglial trogocytosis of presynaptic elements is regulated by the complement system which controls axon morphogenesis in the developing brain.
    1. Cell Biology
    2. Immunology and Inflammation

    Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism

    Leonie Zeitler, Alessandra Fiore ... Peter J Murray
    IL4i1 is an amino acid oxidase expressed in the mammalian immune system and snake venoms, which control diametrically opposite cell protection versus cell death pathways, respectively.
    1. Immunology and Inflammation

    Opposing effects of T cell receptor signal strength on CD4 T cells responding to acute versus chronic viral infection

    Marco Künzli, Peter Reuther ... Carolyn G King
    T cell receptor signal strength correlates positively with Th1 generation during acute infection but negatively during chronic infection.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum

    Kathryn Milne, Alasdair Ivens ... Philip J Spence
    Parasite variants associated with severe malaria do not have an intrinsic growth or survival advantage in vivo, which indicates that a change in host environment is required for their selection.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Loss of circadian protection against influenza infection in adult mice exposed to hyperoxia as neonates

    Yasmine Issah, Amruta Naik ... Shaon Sengupta
    Neonatal hyperoxia abrogates the circadian protection from influenza infection in recovered adults.
    1. Immunology and Inflammation

    Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

    Rabina Mainali, Manal Zabalawi ... Matthew A Quinn
    Integrative multi-omics reveals global dysregulation in hepatic metabolism during prolonged sepsis.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Integration of IL-2 and IL-4 signals coordinates divergent regulatory T cell responses and drives therapeutic efficacy

    Julie Y Zhou, Carlos A Alvarez, Brian A Cobb
    Simultaneous cytokine signaling results in unexpected transcription factor changes that fuel a cellular response divergent from the sum of each cytokine alone.
    1. Cancer Biology
    2. Immunology and Inflammation

    Human primed ILCPs support endothelial activation through NF-κB signaling

    Giulia Vanoni, Giuseppe Ercolano ... Sara Trabanelli
    Circulating human primed innate lymphoid cell precursors have the potential to functionally induce adhesion molecules' expression in endothelial cells and possibly support the immune cells' infiltration into the tumor site.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses

    Olga A Maximova, Daniel E Sturdevant ... Alexander G Pletnev
    Virus infection of the central nervous system disrupts the homeostasis of the immune-neural-synaptic axis via induction of pleiotropic genes with an unintended off-target negative impact on the neurotransmission.