Browse our latest Immunology and Inflammation articles

Redox modification of STING represents a novel target for interferon regulation and control of herpesvirus replication.

Pharmacological activation of the metabolic activities of PKM2 in murine NK cells disrupts cellular redox balance and inhibits optimal NK cell effector functions.

The generation and characterization of true β-catenin null mutant mice conclusively demonstrate that β-catenin is dispensable for T lymphocytes and leukemia stem cells, providing clarifications on a long-standing controversy.

Matrix metalloprotease (MMP)-14 cleaves Tie2 at three distinct sites within the fibronectin type-III (FN3) domain and its pharmacological blockade inhibits Tie2 pathological shedding to exert barrier protective effects.

Surrogate agonist peptide ligands discovered through screening of an IAb-peptide library potentiate expansion of visceral adipose tissue resident regulatory T cells and protect mice from inflammation and improve metabolic indices.

In the absence of human FcgRIIb function, an infection with Borrelia burgdorferi triggers enhanced autoreactive immune responses in humanized mice in vivo.

Circulation of molecules from the brain can serve as a rapid mode of communication from the brain to the liver.

Osterix, a transcription factor regulating osteoblast differentiation and bone formation, is expressed in subsets of CAFs with osteogenic features and marks tumor infiltrating immune populations enriched in immune suppressive markers.

Estrogen aggravates mammary involution through lysosome-mediated cell death, neutrophil recruitment via CXCR2 signalling, neutrophil-mediated inflammation and adipocyte repopulation.

The dendritic cell actin cytoskeleton provides a platform for T cell mechanosensing, delivering novel biophysical cues that serve as costimulatory signals for T cell activation.