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    1. Medicine
    2. Stem Cells and Regenerative Medicine

    A Titin Missense Variant Causes Atrial Fibrillation

    Mahmud Arif Pavel, Hanna Chen ... Dawood Darbar
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology
    2. Medicine

    PCBP2 as an intrinsic agi ng factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis

    Pengbo Chen, Bo Li ... Xinfeng Zheng
    The intrinsic factor of cell senescence, PCBP2, was identified by unlabeled quantitative proteomics, and its biological role in in vitro replication senescence of human bone marrow mesenchymal stromal cells was characterized in vitro.
    1. Medicine

    Three components of glucose dynamics – value, variability, and autocorrelation – are independently associated with coronary plaque vulnerability

    Hikaru Sugimoto, Ken-ichi Hironaka ... Shinya Kuroda
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Medicine

    Time to Eat - A Personalized Circadian Eating Schedule Leads to Weight Loss Without Imposing Calorie Restriction: A Randomized Controlled Pilot Study

    Isabell Wilming, Jana Tuschewski ... Dominic Landgraf
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Incomplete
    1. Immunology and Inflammation
    2. Medicine

    Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

    Ole Bæk, Tik Muk ... Duc Ninh Nguyen
    Reduced parenteral glucose during neonatal infection redirects hepatic metabolism to oxidative phosphorylation and gluconeogenesis, dampens systemic proinflammatory responses, and significantly enhances survival in preterm newborns.
    1. Medicine
    2. Microbiology and Infectious Disease

    Differences in HIV-1 reservoir size, landscape characteristics, and decay dynamics in acute and chronic treated HIV-1 Clade C infection

    Kavidha Reddy, Guinevere Q Lee ... Thumbi Ndung'u
    Extremely early antiretroviral therapy during HIV-1 subtype C infection leads to faster decline in genome-intact viruses, reduced genetic complexity, and immune escape, and may enhance reservoir clearance with additional interventional strategies.
    1. Cancer Biology
    2. Medicine

    Development and assessment of a sustainable PhD internship program supporting diverse biomedical career outcomes

    Patrick Brandt, Dawayne Whittington ... Rebekah L Layton
    Internship programs for PhD and postdoctoral trainees are challenging to develop and sustain, but the benefits to interns and other stakeholders are significant and worth the effort and expense.
    1. Computational and Systems Biology
    2. Medicine

    Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

    Hong Yang, Cheng Zhang ... Adil Mardinoglu
    Inhibiting c-Jun N-terminal kinase exerts a cross-tissue therapeutic effect on metabolic dysfunction induced by sucrose overconsumption in rats.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    R-Spondin Mimetic, SZN-043, Induced Proliferation and Wnt Activity, Two Features Deficient in Human Alcohol-Associated Liver Disease

    Trevor Fisher, Mehaben Patel ... Helene Baribault
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Medicine

    Sperm fertility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA

    Charline Vilpreux, Guillaume Martinez ... Jessica Escoffier
    Revised
    Reviewed Preprint v2
    Updated
    • Inadequate
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