Browse our latest Medicine articles

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    1. Medicine

    PSTPIP2 ameliorates aristolochic acid nephropathy by suppressing interleukin-19-mediated neutrophil extracellular trap formation

    Changlin Du, Chuanting Xu ... Taotao Ma
    PSTPIP2 reduced IL-19 secretion by inhibiting activation of the NF-κB pathway in renal tubular epithelial cells (RTECs), reducing the generation of neutrophil extracellular trap, which can participate in both aristolochic acid I-induced renal injury and apoptosis in RTECs.
    1. Medicine

    Sperm motility in mice with Oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA

    Charline Vilpreux, Guillaume Martinez ... Jessica Escoffier
    1. Immunology and Inflammation
    2. Medicine

    Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice

    Yufang Ding, Karin Yanagi ... Arul Jayaraman
    A microbiome metabolite alleviates liver steatosis and inflammation, and shows its potential as a therapeutic modality for non-alcoholic fatty liver disease.
    1. Medicine

    Autonomous metabolic reprogramming and oxidative stress characterize endothelial dysfunction in acute myocardial infarction

    Erika Zodda, Olga Tura-Ceide ... Marta Cascante
    Acute myocardial infarction patient-derived endothelial cells display a strong mitochondrial proton coupling with excess ROS production, enhanced glutamine metabolism and a carbon source switch from glucose to glutamine.
    1. Medicine

    Metabolomics identifies and validates serum androstenedione as novel biomarker for diagnosing primary angle closure glaucoma and predicting the visual field progression

    Shengjie Li, Jun Ren ... Wenjun Cao
    Metabolomic analyses have developed and validated serum androstenedione as a reliable and effective diagnostic and predictive biomarker for primary angle closure glaucoma in clinical routines.
    1. Medicine

    Viral Infections: Race against dengue

    Swee Sen Kwek, Eng Eong Ooi
    Understanding the kinetics of dengue viruses in the bloodstream can provide insights into the clinical outcomes of the disease.
    Insight
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