A model is proposed to estimate the nuclear export rate of mRNAs produced in a transcription burst, using the spatial distribution of mRNAs determined by single-molecule RNA imaging.
AhCobQ, a novel bacterial lysine deacetylase, functions independently of NAD+ and Zn2+, revealing a previously unknown domain and broad implications for metabolic regulation in prokaryotic systems.
An optimized cytosine base editing system for Leishmania species improves editing efficiency, reduces toxicity, and ensures stable guide expression, enabling scalable loss-of-function screening and efficient creation of functional mutants.
Extremely early antiretroviral therapy during HIV-1 subtype C infection leads to faster decline in genome-intact viruses, reduced genetic complexity, and immune escape, and may enhance reservoir clearance with additional interventional strategies.
Benita Martin-Castaño, Patricia Diez-Echave ... Julio Galvez
Biomarkers of COVID-19 severity identified in nasopharyngeal and faecal microbiota could improve prognostic accuracy and treatment strategies for severe cases.
Vivian C Salgueiro-Toledo, Jorge Bertol ... Rafael Prados-Rosales
Genetic, ultrastructural, multi-omics, and biochemical tools reveal VirR as a central scaffold in Mycobacterium tuberculosis cell envelope remodelling, critical for extracellular vesicle production.
