Browse our latest Microbiology and Infectious Disease articles

Page 86 of 167
    1. Microbiology and Infectious Disease

    A mechanistic model for long-term immunological outcomes in South African HIV-infected children and adults receiving ART

    Eva Liliane Ujeneza, Wilfred Ndifon ... IeDEA-Southern Africa collaboration
    Long-term immune outcomes vary with age, for both adults and children in HIV-infected populations, e.g. long-term scaled carrying capacity is lower in HIV-infected younger individuals compared to older individuals.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Diverse viral proteases activate the NLRP1 inflammasome

    Brian V Tsu, Christopher Beierschmitt ... Matthew D Daugherty
    Proteases from diverse viruses, the first described pathogen-encoded activators of human NLRP1, cleave NLRP1 at a sequence that mimics the viral polyprotein, resulting in inflammasome activation and pro-inflammatory cytokine release.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake

    Marc A Schureck, Joseph E Darling ... Sanjay A Desai
    A high-resolution structure reveals how the RhopH complex traffics within Plasmodium-infected human erythrocytes to serve divergent, essential functions.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Collateral sensitivity associated with antibiotic resistance plasmids

    Cristina Herencias, Jerónimo Rodríguez-Beltrán ... Álvaro San Millán
    Acquisition of antibiotic resistance plasmids induces collateral sensitivity to clinically relevant antibiotics in Escherichia coli, paving the way for targeted 'anti-plasmid' therapies able to preferentially eliminate plasmid-carrying bacteria.
    1. Microbiology and Infectious Disease

    A live attenuated-vaccine model confers cross-protective immunity against different species of the Leptospira genus

    Elsio A Wunder, Haritha Adhikarla ... Albert Ko
    A single dose of a characterized motility-deficient mutant was sufficient to induce robust anti-protein antibodies' response and cross-protective immunity against death and colonization in two different animal models of leptospirosis.
    1. Ecology
    2. Microbiology and Infectious Disease

    The diversity and function of sourdough starter microbiomes

    Elizabeth A Landis, Angela M Oliverio ... Benjamin E Wolfe
    In the most comprehensive survey of sourdough starter biodiversity, this work identifies processes that control the diversity and function of sourdough microbiomes at a continental scale.
    1. Ecology
    2. Microbiology and Infectious Disease

    Freshwater monitoring by nanopore sequencing

    Lara Urban, Andre Holzer ... Maximilian R Stammnitz
    From now on, nanopore metagenomics can be used to monitor aquatic environments with high spatiotemporal resolution, by use of a benchmarked, standardised and cost-effective workflow.
    1. Microbiology and Infectious Disease

    Regulatory roles of Escherichia coli 5' UTR and ORF-internal RNAs detected by 3' end mapping

    Philip P Adams, Gabriele Baniulyte ... Joseph T Wade
    Multiple RNA-seq approaches globally mapped RNA 3´ ends resulting in the discovery of numerous and diverse RNA regulators.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Immunocompetent mouse model for Crimean-Congo hemorrhagic fever virus

    David W Hawman, Kimberly Meade-White ... Heinz Feldmann
    A mouse-adapted strain of Crimean-Congo hemorrhagic fever virus that recapitulates human disease in wild-type mice significantly improves our ability to study Crimean-Congo hemorrhagic fever virus pathogenesis.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Modeling transfer of vaginal microbiota from mother to infant in early life

    Martin Steen Mortensen, Morten Arendt Rasmussen ... Søren Johannes Sørensen
    Modeling weighted transfer ratios enable statistical analysis of maternal–infant transfer at a more general level and can indicate whether any transfer is persistent, transient, or originates from alternate sources.