Microbiology and Infectious Disease

Latest articles

1. 1. Microbiology and Infectious Disease

   Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts

   David Smith et al.

   ATG9-dependent autophagy is an essential pathway for long-term survival within the cyst in the parasite Toxoplasma gondii and could be exploited in future studies seeking interventions against persistent Toxoplasma infection.
2. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii

   Joseph T Clark et al.

   Upon Toxoplasma gondii infection, IL-33 plays a critical role in driving early anti-parasite responses by innate lymphoid cells rendered responsive to its effects by infection.
3. 1. Ecology
   2. Microbiology and Infectious Disease

   A novel ATP dependent dimethylsulfoniopropionate lyase in bacteria that releases dimethyl sulfide and acryloyl-CoA

   Chun-Yang Li et al.
4. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   CRISPR-based functional genomics in human dendritic cells

   Marco Jost et al.

   A CRISPR-based method enables targeted knockouts and genetic screens in human dendritic cells.
5. 1. Chromosomes and Gene Expression
   2. Microbiology and Infectious Disease

   Common virulence gene expression in adult first-time infected malaria patients and severe cases

   J Stephan Wichers et al.

   Parasites with pathogenic variant surface antigens are common in adult malaria patients with a naive immune status.
6. 1. Microbiology and Infectious Disease

   4-hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen

   Hannah Tabakh et al.
7. 1. Microbiology and Infectious Disease

   Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

   Akshay Sabnis et al.

   Modulation of cytoplasmic lipopolysaccharide levels sensitises bacteria to polymyxin antibiotics, revealing a novel combination therapeutic approach.
8. 1. Ecology
   2. Microbiology and Infectious Disease

   Multiple lineages of Streptomyces produce antimicrobials within passalid beetle galleries across eastern North America

   Rita de Cassia Pessotti et al.

   The widespread occurrence of metabolically active streptomycetes in Odontotaenius disjunctus beetle frass may insulate their galleries against pathogenic fungal invasion through the production of diverse antimicrobial specialized metabolites.
9. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3

   Francesco Beghini et al.

   The bioBakery 3 platform enables improved, integrated, and strain-level analysis of microbial communities from large-scale meta-omic data.
10. 1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

    Christophe Caillat et al.

    The structure of gp41with its membrane anchors highlights the flexible linkage of the transmembrane regions and the fuson peptides, which generates an asymmetric conformation, a potential target of MPER bNAbs.