COVID-19: A collection of articles

Collection

1. 1. Medicine

   Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral–bacterial interactions

   Ilja L Kruglikov et al.

   Dysfunctionaladipose tissue puts obese and type 2 diabetic patients at higher risk.
2. 1. Epidemiology and Global Health

   Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

   David W Eyre et al.

   Risk factors for SARS-CoV-2 infection in healthcare workers included caring for Covid-19 patients, Black or Asian ethnicity, and Covid-19-positive household contacts, whereas a bundle of PPE-related measures protected ICU staff.
3. 1. Epidemiology and Global Health

   Quantifying antibody kinetics and RNA detection during early-phase SARS-CoV-2 infection by time since symptom onset

   Benny Borremans et al.

   A meta-analysis shows that seroconversion of antibodies against SARS-CoV-2 is not affected by disease severity and finds higher viral RNA detection probability in lower respiratory tract and fecal samples.
4. 1. Immunology and Inflammation
   2. Medicine

   3D virtual pathohistology of lung tissue from Covid-19 patients based on phase contrast X-ray tomography

   Marina Eckermann et al.

   Phase contrast X-ray tomography based on a combination of parallel and cone beam geometry extends conventional histology by a third dimension and enables full quantication of tissue remodeling in COVID-19.
5. 1. Medicine

   Inference from longitudinal laboratory tests characterizes temporal evolution of COVID-19-associated coagulopathy (CAC)

   Colin Pawlowski et al.

   Longitudinal laboratory testing results tied to SARS-CoV-2 diagnostic PCR results of more than 2500 patients reveal the temporal evolution of COVID-associated coagulopathy.
6. 1. Epidemiology and Global Health

   Early analysis of the Australian COVID-19 epidemic

   David J Price et al.

   An analysis of Australian case data demonstrates how the combined strategy of border measures, case targeted interventions, and social distancing effectively contained the first epidemic wave of COVID-19.
7. 1. Epidemiology and Global Health
   2. Microbiology and Infectious Disease

   The contribution of asymptomatic SARS-CoV-2 infections to transmission on the Diamond Princess cruise ship

   Jon C Emery et al.
8. 1. Medicine

   Concentration-dependent mortality of chloroquine in overdose

   James A Watson et al.

   Most chloroquine regimens trialled for the treatment of COVID19 will not result in life-threatening cardiovascular toxicity.
9. 1. Computational and Systems Biology
   2. Medicine

   A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

   Michael R Garvin et al.

   Gene expression analysis reveals a novel, integrated molecular mechanism for much of the pathogenesis of COVID-19 that provides therapeutic intervention points that can be addressed with existing approved pharmaceuticals.
10. 1. Medicine
    2. Microbiology and Infectious Disease

    Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis

    Tyler Wagner et al.

    Applying deep learning technology for the large-scale curation of symptoms from unstructured EHR clinical notes accurately predicts the differential signals of COVID-19 diagnosis over the week preceding typical PCR testing.
11. 1. Medicine

    Neuropathogenesis of SARS-CoV-2 infection

    Shumayila Khan, James Gomes

    Clinical data of SARS-CoV-2 patients presenting atypical symptoms must be recorded systematically to support continuing research investigating neurological complications associated with COVID-19.
12. 1. Epidemiology and Global Health

    Evidence for transmission of COVID-19 prior to symptom onset

    Lauren C Tindale et al.

    Control of COVID-19 will require strong case finding and isolation of exposed individuals because transmission can occur days prior to symptom onset.
13. 1. Medicine

    Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptors

    AJ Venkatakrishnan et al.

    SARS-CoV-2 receptor ACE2 is expressed in nasal olfactory epithelia, tongue keratinocytes and small intestine enterocytes, connected with the COVID-19 patient phenotypes such as anosmia and diarrhea.
14. 1. Genetics and Genomics
    2. Medicine

    Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

    Roger Pique-Regi et al.

    The human placenta negligibly co-expresses the transcripts encoding the canonical cell-entry mediators for SARS-CoV-2, which explains why mothers with COVID-19 rarely transmit the virus to the fetus.
15. 1. Epidemiology and Global Health
    2. Medicine

    Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

    Nick K Jones et al.

    Diminished incidence of COVID-19 amongst healthcare workers in a comprehensive screening programme demonstrates how effective infection control measures and staff testing can prevent hospitals becoming independent 'hubs' of SARS-CoV-2 transmission.
16. 1. Computational and Systems Biology
    2. Medicine

    SARS-CoV-2 strategically mimics proteolytic activation of human ENaC

    Praveen Anand et al.

    SARS-CoV-2 has evolved to cleverly mimic the FURIN-cleavage site in human ENaC-α, unlike any prior coronavirus strain, shedding new light on the Acute Respiratory Distress Syndrome (ARDS) in COVID-19 patients.
17. 1. Epidemiology and Global Health
    2. Medicine

    Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission

    Lucy Rivett et al.

    3% of >1,000 asymptomatic healthcare workers in their workplace tested positive for SARS-CoV-2, suggesting that comprehensive screening programmes are vital to prevent acquisition of COVID-19 in hospitals.
18. 1. Microbiology and Infectious Disease

    Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization

    PJ Klasse, John P Moore

    Antibodies hold promise for breakthrough treatment of COVID-19, the disease caused by the coronavirus SARS-CoV-2.
19. 1. Medicine
    2. Immunology and Inflammation

    Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome

    Frank L van de Veerdonk et al.

    The kinin-kallikrein system is a crucial target for the treatment of COVID-19.
20. 1. Medicine

    Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients

    Gian Paolo Rossi et al.

    Current evidence does not suggest adverse effects of ACE inhibitors or ARBs in COVID-19 patients and, to the contrary, discontinuing these drugs in these patients may potentially be harmful.
21. 1. Epidemiology and Global Health
    2. Medicine

    Estimated effectiveness of symptom and risk screening to prevent the spread of COVID-19

    Katelyn Gostic et al.

    Even in the best-case scenario, screening for COVID-19 misses well over half of infected travellers.