COVID-19: A collection of articles

Collection

1. 1. Human Biology and Medicine

   Neuropathogenesis of SARS-CoV-2 infection

   Shumayila Khan, James Gomes

   Clinical data of SARS-CoV-2 patients presenting atypical symptoms must be recorded systematically to support continuing research investigating neurological complications associated with COVID-19.
2. 1. Genetics and Genomics
   2. Human Biology and Medicine

   Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

   Roger Pique-Regi et al.

   The human placenta negligibly co-expresses the transcripts encoding the canonical cell-entry mediators for SARS-CoV-2, which explains why mothers with COVID-19 rarely transmit the virus to the fetus.
3. 1. Human Biology and Medicine

   Concentration-dependent mortality of chloroquine in overdose

   James A Watson et al.
4. 1. Computational and Systems Biology
   2. Human Biology and Medicine

   A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

   Michael R Garvin et al.

   Gene expression analysis reveals a novel, integrated molecular mechanism for much of the pathogenesis of COVID-19 that provides therapeutic intervention points that can be addressed with existing approved pharmaceuticals.
5. 1. Human Biology and Medicine
   2. Microbiology and Infectious Disease

   Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis

   Tyler Wagner et al.

   Applying deep learning technology for the large-scale curation of symptoms from unstructured EHR clinical notes accurately predicts the differential signals of COVID-19 diagnosis over the week preceding typical PCR testing.
6. 1. Epidemiology and Global Health
   2. Human Biology and Medicine

   Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

   Nick K Jones et al.

   Diminished incidence of COVID-19 amongst healthcare workers in a comprehensive screening programme demonstrates how effective infection control measures and staff testing can prevent hospitals becoming independent 'hubs' of SARS-CoV-2 transmission.
7. 1. Epidemiology and Global Health
   2. Human Biology and Medicine

   Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission

   Lucy Rivett et al.

   3% of >1,000 asymptomatic healthcare workers in their workplace tested positive for SARS-CoV-2, suggesting that comprehensive screening programmes are vital to prevent acquisition of COVID-19 in hospitals.
8. 1. Microbiology and Infectious Disease

   Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization

   PJ Klasse, John P Moore

   Antibodies hold promise for breakthrough treatment of COVID-19, the disease caused by the coronavirus SARS-CoV-2.
9. 1. Epidemiology and Global Health

   Evidence for transmission of COVID-19 prior to symptom onset

   Lauren C Tindale et al.

   Control of COVID-19 will require strong case finding and isolation of exposed individuals because transmission can occur days prior to symptom onset.
10. 1. Epidemiology and Global Health
    2. Immunology and Inflammation

    Science Forum: A Global lmmunological Observatory to meet a time of pandemics

    Michael J Mina et al.

    The COVID-19 pandemic has clearly demonstrated the need for a global system to monitor the dynamics of susceptibility and immunity, as well as infection, during epidemics and pandemics.
11. 1. Human Biology and Medicine

    Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptors

    AJ Venkatakrishnan et al.

    SARS-CoV-2 receptor ACE2 is expressed in nasal olfactory epithelia, tongue keratinocytes and small intestine enterocytes, connected with the COVID-19 patient phenotypes such as anosmia and diarrhea.
12. 1. Computational and Systems Biology
    2. Human Biology and Medicine

    SARS-CoV-2 strategically mimics proteolytic activation of human ENaC

    Praveen Anand et al.

    SARS-CoV-2 has evolved to cleverly mimic the FURIN-cleavage site in human ENaC-α, unlike any prior coronavirus strain, shedding new light on the Acute Respiratory Distress Syndrome (ARDS) in COVID-19 patients.
13. 1. Human Biology and Medicine
    2. Immunology and Inflammation

    Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome

    Frank L van de Veerdonk et al.

    The kinin-kallikrein system is a crucial target for the treatment of COVID-19.
14. 1. Human Biology and Medicine

    Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients

    Gian Paolo Rossi et al.

    Current evidence does not suggest adverse effects of ACE inhibitors or ARBs in COVID-19 patients and, to the contrary, discontinuing these drugs in these patients may potentially be harmful.
15. 1. Epidemiology and Global Health

    Estimated effectiveness of symptom and risk screening to prevent the spread of COVID-19

    Katelyn Gostic et al.

    Even in the best-case scenario, screening for COVID-19 misses well over half of infected travellers.