Browse our latest Neuroscience articles

Reactivation of paternal Ube3a by an ASO therapy in juvenile and adult mouse models of Angelman syndrome reverses the impairments of EEG power spectrum and sleep pattern, suggesting that these two core disease features may be improved by such therapies.

Experiments on mice suggest that an approach called antisense oligonucleotide therapy may be able to treat some symptoms of Angelman syndrome, including problems with epilepsy and sleep.

Molecular, cellular, and developmental characterization of zebrafish Merkel cells establishes a new model for the study of mechanosensory epidermal cells.

Behavioral and neurophysiological recordings in infant rats reveal that sleep and sensory experience influence neural activity in prefrontal cortex, mirroring similar findings in developing sensorimotor cortex.

Tools and resources to identify transcriptional regulators that create and maintain differences between photoreceptor subtypes.

Direct- and indirect pathway neurons of the posterior striatum display divergent in vivo and ex vivo plasticity after fear learning, and differentially modulate defensive behaviors displayed in the presence, and absence of threat-predicting sensory cues.

Early visual cortex (V1) and hippocampal cortex represent a predictive map of the visual world akin to the successor representation.

Using carefully controlled expression levels and a variety of optical pulse-chase assays in mammalian neurons, an updated model for the polarized transport of synaptic vesicle proteins, and the first steps of synaptic vesicle biogenesis, were uncovered.

Ultrastructural and imaging studies of cochlear ribbon synapses demonstrate cis- and trans-synaptic molecular and structural effects in the absence of the AMPA-type glutamate receptor subunit GluA3 during mouse development in ambient sound levels.

A single-cell RNA-seq study examining gene expression profiles in neurons that underlie Drosophila reproductive behaviors shows males and females build sex-specific behaviors at the molecular-genetic level by overlaying sex-specific information on core gene expression networks.