Browse our latest Neuroscience articles

Endolysosmal trafficking defects, expansion of lysosomes, elevation of ceramides, and disruption of mitochondria are root causes of INAD/PARK14.

Newly identified gain-of-function variants indicate TRPM3 as the cause of a spectrum of autosomal dominant neurodevelopmental disorders with frequent cerebellar involvement in humans.

Volume-EM reconstruction of a whole-body desmosomal connectome including all muscles and their desmosomal partners in a Platynereis larva provides a detailed view of the organisation of the entire locomotor system in an animal.

Neocortical activity is drastically different around awake than sleep hippocampal ripples.

A pathway of unconventional secretion for alpha-synuclein, a protein which may spread in the brain as part of the pathology of Parkinson’s disease.

Neurexins are presynaptic adhesion molecules in the serotonin system which regulate neuron survival and serotonin neuromodulation through active zone formation and serotonin release.

Chemogenetic silencing reveals that entorhinal neurons require ongoing activity for survival, suggesting that their normal physiology may render them vulnerable to pathologies that impair transmission.

Blocking the activity of neurons in a region of the brain involved in memory leads to cell death, which could help explain the spatiotemporal disorientation observed in Alzheimer’s disease.

Bitter-sensing cells across different organs of the fruit fly activate overlapping neural pathways in the brain to regulate a common set of aversive behaviors.

Unprecedented 4D spatiotemporal infant regional cerebral blood flow framework and region-specific physiology–function coupling across infancy were elucidated, highlighting strong physiology–function coupling specifically at the default-mode network to meet extraneuronal metabolic demand for network emergence.