Browse our latest Neuroscience articles

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    1. Neuroscience

    Sharing neurophysiology data from the Allen Brain Observatory

    Saskia EJ de Vries, Joshua H Siegle, Christof Koch
    A growing community demand for open neurophysiology data calls for new standards and tools to help scientists share data from their experiments, find relevant datasets that others have collected, and track data reuse across the literature.
    1. Neuroscience

    Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex

    Mean-Hwan Kim, Cristina Radaelli ... Ed Lein
    Electrophysiological study in human brain slices reveals that short-term synaptic plasticity from presynaptic pyramidal neuron to postsynaptic interneuron connections are target-cell specific based on their subclass interneuron identity.
    1. Neuroscience

    Flexible specificity of memory in Drosophila depends on a comparison between choices

    Mehrab N Modi, Adithya E Rajagopalan ... Glenn C Turner
    Flies can optimally recall a memory with high specificity by comparing options close in time, or default to generalization when they cannot.
    1. Neuroscience

    Neural Circuits: Comparing mouse and human brains

    Hovy Ho-Wai Wong, Christina You Chien Chou ... Per Jesper Sjöström
    Inhibitory circuit motifs in the mouse brain and the human brain are strikingly similar.
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    Insight
    1. Neuroscience

    A tradeoff between acoustic and linguistic feature encoding in spoken language comprehension

    Filiz Tezcan, Hugo Weissbart, Andrea E Martin
    Linguistic features are encoded more strongly during language comprehension than when comprehension is absent, and high word entropy (less constraining context) enhances the encoding of lower-level acoustic and linguistic features while low word entropy suppresses it.
    1. Neuroscience

    α1-Adrenergic receptor–PKC–Pyk2–Src signaling boosts L-type Ca2+ channel CaV1.2 activity and long-term potentiation in rodents

    Kwun Nok Mimi Man, Peter Bartels ... Johannes W Hell
    The α1-adrenergic receptor augments the activity of the L-type Ca2+ channel CaV1.2 through PKC and the tyrosine kinases Pyk2 and Src and thereby synaptic plasticity.
    1. Neuroscience

    Connectomics of the Octopus vulgaris vertical lobe provides insight into conserved and novel principles of a memory acquisition network

    Flavie Bidel, Yaron Meirovitch ... Binyamin Hochner
    Connectomics of the octopus 'fan-out fan-in’ learning network reveals that the intermediate layer uses approximately 22×106 excitatory interneurons, each can store a single sensory input, while approximately 400×103 integrating inhibitory interneurons adjust the network output level.
    1. Neuroscience

    Remapping in a recurrent neural network model of navigation and context inference

    Isabel IC Low, Lisa M Giocomo, Alex H Williams
    Recurrent neural networks trained to navigate and infer latent states exhibit strikingly similar remapping patterns to those observed in navigational brain areas, inspiring new analyses of published data and suggesting a possible function for spontaneous remapping to support context-dependent navigation.
    1. Medicine
    2. Neuroscience

    Presenting a sham treatment as personalised increases the placebo effect in a randomised controlled trial

    Dasha A Sandra, Jay A Olson ... Mathieu Roy
    A laboratory experiment provides the first evidence that framing a sham treatment as personalised to one's genetics and physiology increases its placebo effect on pain.
    1. Neuroscience

    Ketamine’s rapid antidepressant effects are mediated by Ca2+-permeable AMPA receptors

    Anastasiya Zaytseva, Evelina Bouckova ... Seonil Kim
    Ketamine induces the expression of Ca2+-permeable AMPA receptors to enhance synaptic glutamatergic and Ca2+ activity in neurons to cause rapid antidepressant effects.