Browse our latest Neuroscience articles

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    1. Neuroscience

    Innate Behavior: A groom with a view

    Jeffrey E Markowitz
    Mapping mouse grooming episodes to neural activity shows that striatal cells deep in the brain collectively represent key aspects of self-grooming.
    Version of Record
    Insight
    1. Immunology and Inflammation
    2. Neuroscience

    MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

    Em P Harrington, Riley B Catenacci ... Peter A Calabresi
    Oligodendroglia express major histocompatibility complex (MHC) pathways in response to inflammation and MHC reporter mice allow for the investigation of MHC molecule expressing cells in vivo.
    1. Medicine
    2. Neuroscience

    Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer’s disease and neurodegeneration stratified by sex

    Irene Cumplido-Mayoral, Marina García-Prat ... OASIS study
    Brain-Age delta is a non-invasive marker of biological brain aging that is sensitive to the presence of risk factors and altered biomarkers of Alzheimer's disease in non-demented individuals.
    1. Neuroscience

    Hormones: Below the surface of a touch

    Stephanie D Preston, Rosa Muñoz
    How the body and brain respond to a gentle stroke dynamically changes depending on how familiar someone is with the other person.
    Version of Record
    Insight
    1. Neuroscience

    Age-related differences in prefrontal glutamate are associated with increased working memory decay that gives the appearance of learning deficits

    Milena Rmus, Mingjian He ... Matthew R Nassar
    Apparent age-related differences in learning are best accounted for by rapid decay of information in working memory, which is associated with levels of prefrontal glutamate.
    1. Cell Biology
    2. Neuroscience

    Multiple antagonist calcium-dependent mechanisms control CaM kinase-1 subcellular localization in a C. elegans thermal nociceptor

    Domenica Ippolito, Dominique A Glauser
    A refined analysis of the mechanisms controlling CaM kinase-1 subcellular localization in sensory neurons, a cell-autonomous process known to control nociceptive plasticity and to adjust avoidance behaviors.
    1. Neuroscience

    Two forms of asynchronous release with distinctive spatiotemporal dynamics in central synapses

    Gerardo Malagon, Jongyun Myeong, Vitaly A Klyachko
    Asynchronous release is not uniform, but comprises two subpopulations of events, one occurring inside the active zone and another occurring ectopically, which are characterized by distinctive spatiotemporal dynamics in hippocampal synapses.
    1. Neuroscience

    Interplay between external inputs and recurrent dynamics during movement preparation and execution in a network model of motor cortex

    Ludovica Bachschmid-Romano, Nicholas G Hatsopoulos, Nicolas Brunel
    A recurrent neural network model with parameters constrained by data explains mechanisms for how tuning properties of motor cortical neurons change during movement preparation and execution in a monkey performing a reaching task, and accurately reproduces neural dynamics from recordings.
    1. Neuroscience

    In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis

    Maxime Donadieu, Nathanael J Lee ... Daniel S Reich
    Spontaneous remyelination is a common phenomenon in the marmoset experimental autoimmune encephalomyelitis model, reliably detected using in vivo magnetic resonance imaging, rendering this an indispensable model to further investigate the pathobiology of remyelination in multiple sclerosis.
    1. Neuroscience

    cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning

    Xin-Tai Wang, Lin Zhou ... Ying Shen
    Mouse models with specific presynaptic knockout demonstrate that Rim1α is subjected to threonine phosphorylation by a novel EPAC-PKCε module, which is essential to presynaptic transmitter release, required for the induction of presynaptic LTP, and critical for motor learning.