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Hypothalamic stress effector neurons rapidly change activity patterns via recurrent inhibition, representing state-dependent activity switch between baseline and elevated stress levels.

By acting as versatile signal-processors that encode flexible coordinate representations, muscle spindles challenge current widely held views concerning the role of proprioceptors and the peripheral nervous system in sensorimotor function.

The majority of hippocampal neurons in CA3 experience inhibition before and during ripple buildup, while dentate and CA1 cells display depolarizing transients preceding and following ripple onset pointing to a long and orchestrated awake ripple initiation process.

Among three new models for KCNMA1 channelopathy, the most severe gain-of-function variant (Kcnma1^N999S/WT) displays a particular type of immobilizing paroxysmal dyskinesia observed in patients, including amphetamine responsiveness.

Comprehensive multi-neuron fluorescence imaging in C. elegans reveals age-associated changes in neuronal activity that include a breakdown of system-wide organization, changes in neuronal frequency dynamics, and a disruption of the balance between excitatory and inhibitory signaling.

The circadian clock gates sleep drive by modulating sleep homeostat neurons.

Fewer neurons and more glia than previously predicted plus substantial differences between males and females are revealed when entire intact Drosophila larval central nervous systems are quantified using a synthesis of genetic, imaging, and computation technologies.

The predictive power of a computational model advances understanding of the neuronal and circuit biophysical mechanisms that generate the respiratory rhythm and neural activity patterns in the mammalian brainstem.

Sigma oscillations have a dual role in motor memory consolidation depending on their temporal coordination with slow waves during post-learning sleep.

The areas of the cerebral cortex that are necessary for mice to perform goal-directed navigation differ depending on previous experience in cognitively challenging tasks.