Browse our latest Neuroscience articles

Activity-dependent bidirectional changes in phosphorylation of the autism-associated scaffold protein Shank3 are essential for the expression of homeostatic synaptic plasticity.

MDGAs are highly diffusive molecules that alter both neuroligin-1 and AMPA receptor dynamics and function, thereby significantly delaying the differentiation of excitatory post-synapses.

Oxytocin neurons in the paraventricular nucleus of the hypothalamus mediate the increased sociability as a consequence of acute social isolation during adolescence via ventral tegmental area circuits.

The transformation of multiple streams of sensory information into an estimate of body motion occurs between the cerebellum and deep cerebellar nucleus to ensure postural and perceptual stability.

The activity of cerebellar Purkinje cells both represents and participates in organizing the temporal structure of a periodically performed motor action.

When human participants are able to plan responses in a visuo-spatial working memory task, sensory-like representations of remembered spatial position in early visual and parietal cortex adaptively trade off with motor-like representations of upcoming actions in sensorimotor cortex.

Wild-type human recombinant tau protein infused in presynaptic terminals newly assembled microtubules, which sequestered cytosolic dynamins, thereby blocking synaptic vesicle endocytosis and causing activity-dependent rundown of excitatory synaptic transmission in a slice model of mouse brainstem.

In postnatal retina, neuronal apoptosis promotes a spectrum of microglial transcriptional states with varied dependence on CSF1R; TAM receptor Mer and complement receptor 3 mediate phagocytosis of dying neurons while altered CSF1R dependence requires Axl.

A-type fibroblast growth factor homologous factors generate resurgent currents in tetrodotoxin-resistant voltage-gated sodium channels, increase repetitive firing of sensory neurons, and provide a potentially important target for pain treatment strategies.

Local deep hypothermia combined with hibernation-mimicking cold protection is neuroprotective in a translatable large animal model of traumatic optic neuropathy.