Browse our latest Neuroscience articles

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    1. Neuroscience

    Learning of probabilistic punishment as a model of anxiety produces changes in action but not punisher encoding in the dmPFC and VTA

    David S Jacobs, Madeleine C Allen ... Bita Moghaddam
    A novel approach to studying anxiety reveals that learned anxiety and diazepam treatment have unique roles on prefrontal cortex and ventral tegmental area activity.
    1. Neuroscience

    Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through Kv7.4 channel upsurge in auditory neurons and hair cells

    Haiwei Zhang, Hongchen Li ... Ping Lv
    In the cochlea, repressor element 1-silencing transcription factor (REST) regulates the expression levels of Kv7.4 and alterations of REST functions result in progressive hearing loss.
    1. Neuroscience

    Shared mechanisms of auditory and non-auditory vocal learning in the songbird brain

    James N McGregor, Abigail L Grassler ... Samuel J Sober
    A novel, non-auditory learning paradigm reveals that songbirds can modify their vocal output based on somatosensory signals and that a common set of brain pathways underlies both this form of vocal learning and auditory-guided vocal learning.
    1. Neuroscience

    Putting perception into action with inverse optimal control for continuous psychophysics

    Dominik Straub, Constantin A Rothkopf
    A new method for analyzing continuous psychophysics experiments estimates not only perceptual uncertainty from tracking tasks but also action variability, intrinsic costs, and subjective internal models.
    1. Neuroscience

    Functional brain reconfiguration during sustained pain

    Jae-Joong Lee, Sungwoo Lee ... Choong-Wan Woo
    Human neuroimaging with time-evolving network analysis reveals dynamic interactions among multiple functional brain networks in response to sustained pain.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis

    Tianzhi Li, Qiqi Cheng ... Cong Ma
    A new binding mode between Rabphilin 3A and SNAP-25 enables efficient SNARE complex assembly via inducing a conformation change in SNAP-25 SNARE motif.
    1. Neuroscience

    7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome

    Hideaki Tomita, Kelly M Hines ... Libin Xu
    A 7-dehydrocholesterol-derived oxysterol in SLOS was found to profoundly impact neurogenesis during cortical development by interacting with glucocorticoid receptor, which points to new therapeutic approaches for SLOS by targeting the activities of this oxysterol.
    1. Neuroscience

    Time encoding migrates from prefrontal cortex to dorsal striatum during learning of a self-timed response duration task

    Gabriela C Tunes, Eliezyer Fermino de Oliveira ... Marcelo Bussotti Reyes
    Electrophysiological and pharmacological data provide evidence that the medial prefrontal cortex is essential for rats to learn a timing task, becoming unnecessary later, while the dorsal striatum does not play a role initially, taking over when animals become proficient.
    1. Neuroscience

    Distinct population and single-neuron selectivity for executive and episodic processing in human dorsal posterior cingulate

    Lyndsey Aponik-Gremillion, Yvonne Y Chen ... Brett L Foster
    Invasive recordings from human dorsal posterior cingulate cortex show neural population responses occur for only executive tasks, while single neuron responses occur for specific executive or episodic cognitive tasks.
    1. Neuroscience

    Mixed synapses reconcile violations of the size principle in zebrafish spinal cord

    Evdokia Menelaou, Sandeep Kishore, David L McLean
    In the zebrafish spinal cord, mixed synapses contribute to neuronal connectivity and resting excitability, which helps explain violations of the well-known 'size principle' of recruitment.