Humans can rapidly build a new controller when learning continuous movement tasks and can flexibly integrate this process with adaptation of an existing controller.
The bidirectional orbitofrontal cortex-basolateral amygdala circuit helps us to learn the details of predicted rewarding events and then to use that information to make good reward pursuit decisions.
Anders Martin Fjell, Hakon Grydeland ... Kristine Beate Walhovd
Volumetric lifespan change in subcortical structures follows fundamental principles of brain development, lifespan continuity, genetic organization, and age-invariant relationships to cognition.
Two novel mutations in the GRIN2B gene reduce glutamate affinity by >1000-fold, reduce the receptors proton-sensitivity, and exert a dominant-negative effect over receptors in neurons.
The GABA input switching from excitatory to inhibitory during maturation of adult-born dentate granule cells is crucial for their integration into the preexisting circuit.
Sharon R Stevens, Colleen M Longley ... Matthew N Rasband
Analysis of AnkyrinR conditional knockout mice shows that AnkyrinR regulates PV+ fast-spiking interneurons by organizing and maintaining perineuronal nets and through the membrane clustering of Kv3.1b K+ channels.
Humans showed the most widespread asymmetric connectivity between the inferior parietal lobule subregions and the rest of the brain compared to macaques and chimpanzees, which shapes hemispheric specialization in primates.
Kianoush Banaie Boroujeni, Paul Tiesinga, Thilo Womelsdorf
A fast spiking interneuron sub-type in medial and lateral prefrontal cortex fires and gamma-synchronizes prominently during adaptive learning of reward values when outcomes are uncertain and choice options have similar values.
