Browse our latest Neuroscience articles

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    1. Neuroscience

    Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer’s disease

    Alexa Pichet Binette, Guillaume Theaud ... PREVENT-AD Research Group
    White matter microstructure alterations in key bundles affected in Alzheimer's disease are related to amyloid and tau pathology in the preclinical phase of sporadic and autosomal-dominant Alzheimer's disease.
    1. Neuroscience

    Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses

    Michael Bucher, Stephan Niebling ... Marina Mikhaylova
    Autism-associated SHANK3 missense mutations result in differential protein folding, stability, and intramolecular dynamics affecting its turnover at the synapse.
    1. Neuroscience

    Sniff-synchronized, gradient-guided olfactory search by freely moving mice

    Teresa M Findley, David G Wyrick ... Matthew C Smear
    To track odors borne on turbulent airflow, mice strategically follow their nose, with sampling movements and sensory computations reminiscent of those demonstrated in nematodes and insects.
    1. Neuroscience

    Anticipation of temporally structured events in the brain

    Caroline S Lee, Mariam Aly, Christopher Baldassano
    The brain contains a hierarchy of anticipatory signals, with more anterior regions showing anticipation that reaches further into the future.
    1. Neuroscience

    Songbirds can learn flexible contextual control over syllable sequencing

    Lena Veit, Lucas Y Tian ... Michael S Brainard
    Songbirds can use arbitrary visual cues to immediately, flexibly and adaptively control syntax of learned song vocalizations in a manner that parallels human cognitive control over syllable sequencing in speech.
    1. Genetics and Genomics
    2. Neuroscience

    Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology

    Eric N Anderson, Andrés A Morera ... Udai Bhan Pandey
    Traumatic injury leads to functional defects in nucleocytoplasmic transport and TDP-43 pathology in multiple model systems.
    1. Neuroscience

    Presynaptic inhibition of dopamine neurons controls optimistic bias

    Nobuhiro Yamagata, Takahiro Ezaki ... Hiromu Tanimoto
    The subcellular activity of presynaptic terminals of dopamine neurons shapes the reward magnitude and memory specificity.
    1. Neuroscience

    Enhanced excitability of cortical neurons in low-divalent solutions is primarily mediated by altered voltage-dependence of voltage-gated sodium channels

    Briana J Martiszus, Timur Tsintsadze ... Stephen M Smith
    External calcium regulates neuronal excitability via its actions on voltage-gated sodium channels but not by regulating NALCN via the calcium-sensing receptor.
    1. Medicine
    2. Neuroscience

    Recovery of consciousness and cognition after general anesthesia in humans

    George A Mashour, Ben JA Palanca ... Max B Kelz
    Cognitive reconstitution after pharmacologic unconsciousness is an extended process, executive function is more robust than expected, and the healthy human brain is resilient to the effects of deep general anesthesia.
    1. Neuroscience

    Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum

    Marta Maltese, Jeffrey R March ... Nicolas X Tritsch
    In addition to modulating firing rates, the neurotransmitter dopamine exerts a strong influence on the overall number of neurons in striatum that are recruited during behavior.