Browse our latest Neuroscience articles

Distinct dorsal periaqueductal gray ensembles encode threat approach and avoidance behavioral states.

A dopamine transporter deficiency syndrome (DTDS)-linked mutation, R445C, underlies dopamine dysfunction and, more broadly, the clinical phenotypes shared by DTDS and Parkinson’s disease.

Identification of causal genes and their effects on other biological determinants untangles the complexities of aging and Alzheimer's and can facilitate drug discovery for sustaining healthy aging and treating Alzheimer's.

In models of chronic migraine, neuronal complexity is diminished in head-pain processing regions but restored through HDAC6 inhibition, which increases tubulin acetylation and cytoskeletal flexibility, and CGRP receptor blockade.

Intra-individual variability in choice, response time, subjective effort, confidence, and choice-induced preference change and certainty gain is explained by a cost–benefit model of cognitive resource allocation.

The direct interaction of R-type Ca²⁺ channel Cav2.3 and GABA_B receptor auxiliary subunits in the active zone of medial habenula terminals scales synaptic strength independent of GABA_B receptor activation.

Computational modeling, and empirical behavioral and EEG results show that learning relies not only on comparing current events to past experience, but integrates response-based outcome predictions and confidence.

Somatic instability of the CAG repeat increases progressively with age and disease progression in Huntington disease mutation carriers, starting with low levels in fetal brain tissues.

Immunohistochemical labeling of antigens deep within mouse brain tissue sections was achieved without the need for lipid permeabilization, thereby preserving tissue ultrastructure and enabling correlative light and electron microscopy studies.

A fully automated workflow for high-throughput mouse behavioral and optogenetic experiments in homecage reveals involvement of brain regions in tactile decision-making.