Browse our latest Neuroscience articles

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    1. Neuroscience

    Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability

    Yuliya Voskobiynyk, Jonathan R Roth ... Erik D Roberson
    BIN1 forms a complex with Tau and voltage-gated calcium channels in neurons, and higher BIN1 levels promote neuronal activity, calcium influx, and bursting that is blocked by reducing Tau.
    1. Neuroscience

    Stable and dynamic representations of value in the prefrontal cortex

    Pierre Enel, Joni D Wallis, Erin L Rich
    The prefrontal cortex encodes both stable and dynamic representations of expected value, providing mechanisms to support robust as well as flexible access to value information during temporal delays.
    1. Neuroscience

    Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo

    Jui-Yi Hsieh, Brittany N Ulrich ... Diane M Papazian
    Electrophysiological analysis and imaging in live zebrafish reveal that infant- and adult-onset SCA13 mutations have distinct effects on the electrical activity, development, and survival of cerebellar Purkinje cells.
    1. Medicine
    2. Neuroscience

    Deciphering the neural signature of human cardiovascular regulation

    Jorge Manuel, Natalia Färber ... Florian Beissner
    At least three hypothalamic subsystems are involved in cardiovascular regulation in humans.
    1. Neuroscience

    Shared and specific signatures of locomotor ataxia in mutant mice

    Ana S Machado, Hugo G Marques ... Megan R Carey
    LocoMouse analysis of severely ataxic reeler mutant mice reveals fundamental features of locomotor ataxia and provides a roadmap for linking high-dimensional behavioral phenotyping to alterations in underlying neural circuits.
    1. Neuroscience

    Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain

    David Cabañero, Angela Ramírez-López ... Rafael Maldonado
    Operant drug self-administration in a mouse model of neuropathic pain reveals pain-relieving effects of a cannabinoid CB2 receptor agonist that are mediated through CB2 receptors of neurons and lymphocytes.
    1. Computational and Systems Biology
    2. Neuroscience

    Movement initiation and grasp representation in premotor and primary motor cortex mirror neurons

    Steven Jack Jerjian, Maneesh Sahani, Alexander Kraskov
    Mirror neurons, including corticospinal neurons, in primary motor cortex of macaque monkeys, clearly dissociate between execution and observation of grasping actions while ventral premotor cortex (F5) maintains a similar representation.
    1. Neuroscience

    Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling

    Naomi AK Hanemaaijer, Marko A Popovic ... Maarten HP Kole
    High-speed calcium imaging from the axon initial segment shows that sodium channels are in part permeable to calcium ions.
    1. Neuroscience

    Alterations in the intrinsic properties of striatal cholinergic interneurons after dopamine lesion and chronic L-DOPA

    Se Joon Choi, Thong C Ma ... Un Jung Kang
    HCN and SK channel currents in striatal cholinergic neurons are decreased with dopamine loss, but only HCN is restored by chronic L-DOPA and SK abnormality persists in dyskinesia.
    1. Neuroscience

    Private–public mappings in human prefrontal cortex

    Dan Bang, Sara Ershadmanesh ... Stephen M Fleming
    A distinction between private and public aspects of mental states is reflected in a medial-lateral division of human prefrontal cortex.