The substrate for evolutionary divergence does not lie in changes in neuronal cell number or targeting, but rather in sensory perception and synaptic partner choice within invariant, prepatterned neuronal processes.
SOM+ GABAergic neuronal signaling and inhibitory transmission in the central lateral amygdala is regulated by TMEM16B, which is also involved in fear and anxiety-like behaviors.
Motor fatigability is associated with a decrease in inhibition throughout the motor network, suggesting that selective inhibitory control is a key mechanism to maintain motor efficiency during repetitive movements.
Sister projection neurons in the mammalian olfactory system do not share sensory synaptic input indicating that lineage-independent mechanisms regulate their synaptic connectivity with the olfactory sensory neurons.
Oleksandr Yagensky, Mahdokht Kohansal-Nodehi ... John JE Chua
Increased levels of brain Hebp1 starting from the presymptomatic stage of Alzheimer’s disease contributes to progressive neuronal loss by triggering mitochondrial-dependent apoptosis in neurons exposed to elevated heme.
Merse E Gáspár, Pierre-Olivier Polack ... Gergő Orbán
Firing rate nonlinearity recovers linear decodability of orientation information from simple cells of the primary visual cortex under uncertainty of nuisance parameters phase and spatial frequency.
Paolo Campus, Ignacio R Covelo ... Shelly B Flagel
A top-down circuit generating from the prelimbic cortex and projecting to the paraventricular nucleus of the thalamus mediates individual differences in cue-elicited responding by affecting subcortical dopamine-dependent incentive learning.
An fMRI experiment reveals distinct brain regions that respond in a graded manner as humans process distance information across increasing spatial scales.
When subjects perform spatial judgments in environments of increasing scale, brain activity shifts along posterior-anterior gradients, advancing from the visual system to the default-mode network.
Eduard Ort, Johannes Jacobus Fahrenfort ... Christian NL Olivers
During search for multiple targets, individuals can efficiently prepare to select multiple target objects simultaneously, but the actual selection of those objects from the sensory input is limited.
