Xiangling Meng, Christopher M McGraw ... Huda Y Zoghbi
A combination of mouse genetics and biochemistry approaches reveals neurexophilin4 (Nxph4) as a context-specific α-neurexin ligand, which regulates Golgi-granule cell inhibitory synapses and motor functions.
The ASAP initiative will incentivize collaboration between researchers and encourage open-science practices to improve our understanding of the biology underlying Parkinson's disease.
Neural populations may depend on balanced recurrent connectivity to produce an efficient stimulus representation while also maintaining an accurate stimulus encoding despite the variability introduced by adapting neural responses.
Anna Vavakou, Nigel P Cooper, Marcel van der Heijden
The cells in our inner ear commonly believed to provide fast mechanical feedback are too sluggish to follow the vibrations evoked by high-frequency sounds.
The neural representation of position in the medial entorhinal cortex may be stabilized by synaptic connectivity across modules, which enforces coherent updates in their states.
Brooks G Robinson, Xintong Cai ... Pascal S Kaeser
Midbrain dopamine neurons use sophisticated secretory machinery to establish specialized sites for action potential-evoked release of dopamine from their cell bodies and dendrites.
Julia L Meng, Zarion D Marshall ... Ellie S Heckscher
In vivo stem cell reprogramming in the well-studied stem cell NB7-1 using the classic temporal transcription factor Hunchback increases motor neuron number and re-specifies dendritic morphology and neuromuscular synaptic partnerships.
Marisa M Brockmann, Marta Maglione ... Dietmar Schmitz
The active zone scaffold protein RIM-BP2 performs distinct functions in vesicle release at two hippocampal synapses, providing insights on how synapses express diversity in release properties.
Neurons in the striatum exhibited periodic firing in monkeys attempting to detect omission of repetitive visual stimulus, while the phase of neuronal activity differed from that observed in the cerebellum.
