Browse our latest Neuroscience articles

The ongoing debate on the neural basis of orientation selectivity in the primary visual cortex continues.

Perceptual decision making in monkeys can be manipulated by using optogenetics to inactivate functional subregions of visual cortex, but the brain has a capacity to compensate for this perturbation.

Structure of the triheteromeric α1β1γ2S GABAA receptor in complex with GABA illuminates the principles of receptor assembly and agonist binding.

Intracranial recordings of human brain activity during awakening from general anesthesia exhibit a brief brain state not seen during loss of consciousness, in which stimuli elicit large electrophysiological responses that resemble those seen in sleep.

Shootin1a, through its spatially regulated phosphorylation within growth cones, mediates the gradient reading and mechanoresponse for netrin-1-induced axon guidance.

Immunolabelling and morphological assessment, complemented by complete transcriptomic analysis, demonstrates that supporting cells can be induced to convert towards a hair cell-like phenotype in human vestibular sensory epithelia.

The hypoxia-inducible factor HIF drives transcription of the gene cyp-36A1, which encodes a cytochrome P450 enzyme that acts via a putative intercellular signal to regulate the nuclear receptor NHR-46 and consequently stress resistance and behavior.

A novel experimental method and analysis is conceived, based on perturbation and sparse recording, to elucidate the circuit structure and mechanisms underlying the responses of grid cells.

Active zone release probability is correlated with calcium channel density and calcium influx at single release sites, with release strength increasing in an activity-dependent manner during synapse maturation.

In C. elegans, presenilin functions, independent of its gamma-secretase proteolytic activity, to regulate mitochondrial metabolism by controlling ER-mitochondrial calcium transfer and, even in the absence of Abeta signaling, loss of this activity leads to neurodegeneration.