Neuroligin 1 is a critical adhesion molecule which organizes AMPA receptor nanodomains in close vicinity to pre-synaptic release sites, and whose genetic or chemical disruption severely impairs synaptic transmission properties.
Atoh1 promotes the development of two different neural circuits involved in hypoxic and hypercapnic respiratory responses that together are essential for neonatal respiratory drive and survival.
Plexin controls the spatial distribution of synapses by locally inhibiting Rap2 small GTPase activity along the axon, and a Rap2 effector, TNIK, which also plays a key role in inhibiting synapse number.
Andrew T Moehlman, Amanda K Casey ... Helmut Krämer
Tuning of BiP activity by Fic-mediated AMPylation is required for Drosophila photoreceptor plasticity and attenuation of the unfolded protein response.
Principal neurons of the brainstem nucleus comparing sound level at the two ears do not have the slow response properties previously attributed to them, but are instead specialized for fast weighing of excitation and inhibition.
A new mechanism linking lysosomes to mTOR regulation and synaptic plasticity involves p18 ubiquitination by Ube3a, and underlies some of the pathology observed in Angelman syndrome.
Studies that looked into how the auditory brainstem processes the difference in the intensity of a sound as it reaches each ear may have wrongly assumed which neurons were being recorded.
