Cryo-electron tomography, reconstitution, and electrophysiological data show that a fundamental function of Munc13-1 is to bridge synaptic vesicles to the presynaptic plasma membrane.
The transition in basal ganglia output from the healthy to the diseased state is biphasic, stereotyped across models, and suggests key time points for delivering therapeutic interventions.
As the first fully genetically encoded method, PARIS allows cell-specific, long-term, repeated measurements of gap junctional coupling with high spatiotemporal resolution, facilitating its study in both health and disease.
Inhibitory noninvasive stimulation to the precuneus disrupts theta and gamma oscillatory coupling between medial temporal lobes and neocortical regions during complex personal memory retrieval.
L Bailey Lindenmaier, Nicolas Parmentier ... Kevin M Wright
Dystroglycan interacts with multiple partners, including the transmembrane receptor Celsr3, to regulate axon tract formation throughout the developing nervous system.
The basis for small-molecule block, insights into gating, and an unexpected architectural role for the lipid membrane are revealed in structures of the volume regulated anion channel LRRC8A.
