Homotypic olfactory receptor neurons in Drosophila, including CO2-sensing neurons with distinctive sheet-like dendrites, exhibit unexpected morphological diversity that may underlie functional adaptability.
Johanna Ganssauge, Sophie Hawkins ... Akshay Bhinge
A novel human iPSC-derived model induces mislocalization of endogenous TDP-43 without mutations or stress, recapitulating key ALS features including deficits in neuronal loss and morphology, splicing errors, and microRNA dysregulation.
The BRAIN Circuits Program of the NIH BRAIN Initiative has impacted how fundamental discovery in integrative systems neuroscience is investigated, commensurate with the complexity to address neurobehavioral and neurological dysfunctions.
Formation of specialized ribbon synapses in sensory hair cells involves dynamic precursor movement, microtubule-guided transport, and precursor fusion, culminating in synapse assembly essential for hearing and balance.
Failure in sexual behaviors suppresses sweet taste perception of male fruit flies, by dampening dopaminergic signaling between mating-related neural circuits and peripheral gustatory pathways.
ABBA ensures proper cortical development by regulating radial glial division through RhoA activity at the cleavage furrow, and its mutation results in developmental abnormalities linked to microcephaly.
