Genome-wide RNA-seq analysis of single cells of the developing mouse endolymphatic sac reveals its molecular-cellular architecture and a model for salt and fluid absorption required for acquisition of normal inner ear structure and function.
Jerome Robert, Emily B Button ... Cheryl L Wellington
Modelling beta-amyloid deposition in bioengineered human vessels represents a notable advance to further investigate the role of the vasculature in Alzheimer's disease.
Humans adjust the degree to which they learn from positive relative to negative outcomes as a function of how informative they estimate those outcomes to be.
Mattia Volta, Dayne A Beccano-Kelly ... Austen J Milnerwood
LRRK2 G2019S knock-in mice are a genetically faithful model that recapitulates the slow disease progression of familial PD, with initial alterations to behaviour and neurotransmission providing early pathophysiological targets for neuroprotective interventions.
Milos Radivojevic, Felix Franke ... Douglas J Bakkum
A method was developed to non-invasively and simultaneously track individual action-potentials propagating across multiple branches of identified neurons in neocortical cultures.
Esteban J Beckwith, Quentin Geissmann ... Giorgio F Gilestro
Sexual arousal, exposure to aphrodisiac pheromones, or mere activation of peripheral pheromone-sensing neurons can modulate sleep homeostasis and are able to counteract the effects of sleep deprivation in Drosophila.
Sachiko Murase, Crystal L Lantz, Elizabeth M Quinlan
Light reintroduction (LRx) after dark exposure reactivates structural and functional plasticity in the adult mouse visual cortex by increasing the activity of MMP-9 at thalamo-cortical synapses.
