Browse our latest Neuroscience articles

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    1. Computational and Systems Biology
    2. Neuroscience

    Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition

    Veronica Musante, Lu Li ... Angus C Nairn
    A complex interplay between MAST3 and PKA protein kinases and the regulatory protein ARPP-16 allows cAMP to control the activity of protein phosphatase 2A.
    1. Neuroscience

    A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice

    Kylie S Chew, Jordan M Renna ... Samer Hattar
    A single subpopulation of photoreceptors constitutes a shared node in the neural networks that regulate light-dependent maturation of the circadian clock and light-independent refinement of retinal ganglion cell projections to the brain.
    1. Developmental Biology
    2. Neuroscience

    The laminar organization of the Drosophila ellipsoid body is semaphorin-dependent and prevents the formation of ectopic synaptic connections

    Xiaojun Xie, Masashi Tabuchi ... Alex L Kolodkin
    The organization of layered/laminated axon projections in specific regions of the fruitfly central brain is regulated by short-range repulsive guidance and is critical for local inhibitory circuit formation and function.
    1. Neuroscience

    Dye-enhanced visualization of rat whiskers for behavioral studies

    Jacopo Rigosa, Alessandro Lucantonio ... Mathew E Diamond
    A simple fluorescent dye method allows visualization of whiskers, facilitating studies of rodent tactile behavior.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers

    Hansen Wang, Lisa D Muiznieks ... Gerold Schmitt-Ulms
    The cyclic neuropeptide somatostatin binds to human Aβ1-42 through an interface that critically relies on a specific tryptophan, thereby blocking the propensity of Aβ to aggregate, a critical step in the pathobiology of Alzheimer's disease.
    1. Ecology
    2. Neuroscience

    Individual recognition and the ‘face inversion effect’ in medaka fish (Oryzias latipes)

    Mu-Yun Wang, Hideaki Takeuchi
    Medaka fish were able to use faces for individual recognition, and were slower to recognise inverted faces but not inverted non-face shapes.
    1. Neuroscience

    Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion

    Steven Knafo, Kevin Fidelin ... Claire Wyart
    Bioluminescence monitoring and selective silencing in zebrafish larva reveal a novel sensorimotor circuit modulating speed in the moving spinal cord.
    1. Neuroscience

    Cortex-dependent recovery of unassisted hindlimb locomotion after complete spinal cord injury in adult rats

    Anitha Manohar, Guglielmo Foffani ... Karen A Moxon
    After complete spinal transection in adult rats, careful combinations of pharmacological and physical therapies create a novel cortical sensorimotor circuit that may bypass the lesion through biomechanical coupling, allowing animals to recover unassisted hindlimb locomotion.
    1. Neuroscience

    Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling

    Erinn S Gideons, Pei-Yi Lin ... Lisa M Monteggia
    The antimanic action of lithium requires BDNF-TrkB signaling coupled with enhanced dynamin-dependent endocytosis of AMPARs as a potential mechanism underlying the therapeutic effects.
    1. Cell Biology
    2. Neuroscience

    Glycolytic reliance promotes anabolism in photoreceptors

    Yashodhan Chinchore, Tedi Begaj ... Constance L Cepko
    Aerobic glycolysis in rod photoreceptors of adult mice is regulated by allostery and FGF signaling and is required for maintaining outer segments.