Browse our latest Physics of Living Systems articles

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    1. Computational and Systems Biology
    2. Physics of Living Systems

    A mathematical model for ketosis-prone diabetes suggests the existence of multiple pancreatic β-cell inactivation mechanisms

    Sean A Ridout, Priyathama Vellanki, Ilya Nemenman
    A simple mathematical model, incorporating reversible deactivation of β-cells, can potentially explain the rapid onset and remission of a diabetes subtype, ketosis-prone diabetes.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Polyphosphate discriminates protein conformational ensembles more efficiently than DNA promoting diverse assembly and maturation behaviors

    Saloni Goyal, Divya Rajendran ... Athi N Naganathan
    Polyphosphate, a universal stress response regulator, binds distinctively to different starting ensembles of the same protein leading to either condensates or aggregates that in turn can solubilize or further aggregate, showcasing their ability to finely control the assembly process.
    1. Physics of Living Systems

    Toward Stable Replication of Genomic Information in Pools of RNA Molecules

    Ludwig Burger, Ulrich Gerland
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

    Ka Kiu Lee, Urszula Łapińska ... Stefano Pagliara
    Sub-populations of non growing bacteria survive treatment with antimicrobial peptides by mounting an efflux response.
    1. Neuroscience
    2. Physics of Living Systems

    Responses to membrane potential-modulating ionic solutions measured by magnetic resonance imaging of cultured cells and in vivo rat cortex

    Kyeongseon Min, Sungkwon Chung ... Jang-Yeon Park
    Magnetic resonance imaging, through its sensitivity to ionic environments that modulate membrane potential, enables noninvasive assessment of biological systems.
    1. Physics of Living Systems

    Role of intercellular adhesion in modulating tissue fluidity

    Soumyadipta Ray, Santidan Biswas, Dipjyoti Das
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Designing biochemical circuits with tree search

    Pranav S Bhamidipati, Matthew Thomson
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience
    2. Physics of Living Systems

    The geometry and dimensionality of brain-wide activity

    Zezhen Wang, Weihao Mai ... Quan Wen
    Neural activity patterns in randomly sampled neuron groups statistically match whole-brain dynamics, revealing a scale-invariant organizational principle that enables robust and efficient computation across brain regions and species.
    1. Developmental Biology
    2. Physics of Living Systems

    Spectral decomposition unlocks ascidian morphogenesis

    Joel Dokmegang, Emmanuel Faure ... Madhav Mani
    The blueprint and narrative of shape formation during early development can be objectively observed by quantifying and analyzing whole-embryo dynamics.
    1. Physics of Living Systems

    Theory of non-dilute binding and surface phase separation applied to membrane-binding proteins

    Xueping Zhao, Daxiao Sun ... Christoph A Weber
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
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