Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Defining the ultrastructure of the hematopoietic stem cell niche by correlative light and electron microscopy

    Sobhika Agarwala, Keun-Young Kim ... Owen J Tamplin
    Multiple imaging modalities resolved the ultrastructure of single hematopoietic stem cells in their endogenous niche, allowing identification of dopamine beta-hydroxylase positive cells as a functional niche cell type.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Development: Shining a light on hematopoietic stem cells

    Anne Schmidt
    A combination of light and electron microscopy has revealed further details about the location and interactions of hematopoietic stem and progenitor cells.
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    1. Stem Cells and Regenerative Medicine

    Generation of functional hepatocytes by forward programming with nuclear receptors

    Rute A Tomaz, Ekaterini D Zacharis ... Ludovic Vallier
    Forward programming of human pluripotent stem cells with a combination of four transcription factors allows the production of functional hepatocytes.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Full spectrum flow cytometry reveals mesenchymal heterogeneity in first trimester placentae and phenotypic convergence in culture, providing insight into the origins of placental mesenchymal stromal cells

    Anna Leabourn Boss, Tanvi Damani ... Anna ES Brooks
    Full spectrum flow cytometry reveals a high degree of placental mesenchymal cell heterogeneity, which is lost with culture, highlighting the importance of detailed ex vivo phenotyping to optimise the use of these cells in downstream applications.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Decoding the activated stem cell phenotype of the neonatally maturing pituitary

    Emma Laporte, Florian Hermans ... Hugo Vankelecom
    The neonatally maturing pituitary harbors an activated stem cell compartment and shows prominent regenerative capacity, as revealed by single-cell transcriptomic profiling and in vitro (organoid) and in vivo (mouse) exploration.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells

    Daniela Ávila-González, Wendy Portillo ... Néstor F Díaz
    Interaction of human embryonic stem cells (hESC) with human amniotic epithelial cells (hAEC) confers hESC a pluripotent potential that resembles the anteriorized epiblast, which is predisposed to form the neural ectoderm.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Cell Culture: Implementing robotics and artificial intelligence

    Sujith Sebastian
    An automated platform for cell culture combines robotics and artificial intelligence to optimize cell culture protocols and reliably produce specific cell types that could be used for regenerative medicine treatments.
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    1. Stem Cells and Regenerative Medicine

    Comparison of freshly cultured versus cryopreserved mesenchymal stem cells in animal models of inflammation: A pre-clinical systematic review

    Chintan Dave, Shirley HJ Mei ... Lauralyn McIntyre
    Administration of cryopreserved as compared freshly cultured MSCs do not appear to negatively impact measures of in vivo efficacy or in vitro potency in animal models of inflammation.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Functional requirements for a Samd14-capping protein complex in stress erythropoiesis

    Suhita Ray, Linda Chee ... Kyle J Hewitt
    Genetic complementation approaches in a mouse model of anemia reveals new protein interactions which aid cell survival and promote sensing of environmental cues.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Generation of vascularized brain organoids to study neurovascular interactions

    Xin-Yao Sun, Xiang-Chun Ju ... Zhen-Ge Luo
    A vessel and brain fusion organoid model provides a platform for the study of interactions between neuronal and non-neuronal components during brain development and functioning.