Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis

    Arantxa Cebrian-Silla et al.
    Adult neural stem cells differ in the types of neurons they generate according to their location and new territories and genes associated with dorsal and ventral neurogenic lineages in the adult mouse brain are revealed.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells

    Suhong Sun et al.
    Adult cochlear supporting cells (SCs) are plastic and respond to ectopic Ikzf2 and Atoh1, and hair cell damage by up-regulating HC and down-regulating their endogenous SC genes.
    1. Stem Cells and Regenerative Medicine

    TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells

    Anna Osnato et al.
    Identifying the pathways that support human naive-state pluripotent stem cells provides insights into the signalling-based regulation of human pluripotency and enables informed decisions to improve conditions for pluripotent cell culture.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Insulin-producing β-cells regenerate ectopically from a mesodermal origin under the perturbation of hemato-endothelial specification

    Ka-Cheuk Liu et al.
    Genetic analyses revealed the remarkable plasticity of mesodermal cells to differentiate across the germ layers to form insulin-producing β-cells, which are normally of endodermal origin.
    1. Stem Cells and Regenerative Medicine

    Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes

    Francis Grafton et al.
    Deep learning combined with induced pluripotent stem cell technology is an effective method to interrogate cellular phenotypes and predict patterns of cardiotoxicity in vitro.
    1. Stem Cells and Regenerative Medicine

    Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging

    Jacqueline A Larouche et al.
    Muscle stem cells locally respond to perturbations of motor neurons and the neuromuscular junction.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    AAV ablates neurogenesis in the adult murine hippocampus

    Stephen Johnston et al.
    Future work using recombinant AAV as an experimental tool in the dentate gyrus or as a gene therapy for diseases of the central nervous system should be carefully evaluated.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

    Shintaro Ide et al.
    Ferroptotic stress enhances the accumulation of damage-associated inflammatory proximal tubular cell state, thereby promoting maladaptive renal repair and the AKI-to-CKD transition.
    1. Stem Cells and Regenerative Medicine

    Distinct skeletal stem cell types orchestrate long bone skeletogenesis

    Thomas H Ambrosi et al.
    Functional and molecular analyses of two distinct skeletal stem cell populations establish the important role of stem cell diversity that provides a framework for novel investigations into skeletal biology.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    A deep learning algorithm to translate and classify cardiac electrophysiology

    Parya Aghasafari et al.
    A deep learning network can classify cardiac myocytes into drug-free and drugged categories and predict the impact of electrophysiological perturbation across the continuum of aging.