Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Adult chondrogenesis and spontaneous cartilage repair in the skate, Leucoraja erinacea

    Aleksandra Marconi et al.
    The ability of cartilaginous fishes to generate new cartilage through adulthood, and to spontaneously repair damaged cartilage, could shed light on novel cell-based therapies for cartilage injury in mammals.
    1. Stem Cells and Regenerative Medicine

    Long non-coding RNA GRASLND enhances chondrogenesis via suppression of the interferon type II signaling pathway

    Nguyen PT Huynh et al.
    Bioinformatic analysis of mesenchymal stem cell chondrogenesis identified a novel long noncoding RNA, GRASLND, which suppresses interferon signaling and enhances chondrogenesis.
    1. Stem Cells and Regenerative Medicine

    Stem Cells: Encouraging cartilage production

    H Scott Stadler
    A long non-coding RNA called GRASLND is essential to help stem cells create stable cartilage.
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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Zebrafish embryonic explants undergo genetically encoded self-assembly

    Alexandra Schauer et al.
    Blastoderm tissue organization and patterning in zebrafish explants is driven by a genetically encoded and controlled self-assembly mechanism, rather than a bonafide self-organization mechanism.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Cell and molecular transitions during efficient dedifferentiation

    John ME Nichols et al.
    Efficient dedifferentiation is characterized by robustness to mutation, flexibility in ordering of cellular events and reversal of developmental changes along a single gene expression trajectory.
    1. Stem Cells and Regenerative Medicine

    Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury

    Terren K Niethamer et al.
    Single-cell RNA sequencing reveals extensive endothelial cell (EC) heterogeneity throughout the lung vasculature and identifies two distinct populations, Car4-high ECs and proliferative ECs, that preferentially respond to lung injury.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    EphA7 promotes myogenic differentiation via cell-cell contact

    Laura L Arnold et al.
    The juxtacrine signaling molecule EphA7, when expressed on terminally-differentiated myocytes, non-cell-autonomously induces adjacent myoblasts to also commit to terminal differentiation leading to rapid coordinated differentiation across the entire population.
    1. Human Biology and Medicine
    2. Stem Cells and Regenerative Medicine

    Functionally heterogeneous human satellite cells identified by single cell RNA sequencing

    Emilie Barruet et al.
    Single cell RNA sequencing leads to identification and separation of transcriptionally and functionally heterogeneous, natural human satellite cells, including a subpopulation marked by CAV1 harboring quiescence phenotypes and engraftment potential.
    1. Human Biology and Medicine
    2. Stem Cells and Regenerative Medicine

    Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence

    Nicola Alessio et al.
    Protein IGFBP-4 acts as a genotoxic stress mediator that, entering into circulation after its secretion by senescent cells, could promote further senescence phenomena in non-injured cells thus impairing tissues’ homeostasis.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Cell-type diversity and regionalized gene expression in the planarian intestine

    David J Forsthoefel et al.
    Application of laser-capture microdissection to planarian intestinal tissue provides a new tool for analysis of tissue-specific gene expression in flatworms, and a new resource to advance investigations of gastrointestinal regeneration.