Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Stem Cells and Regenerative Medicine

    Ex vivo expansion potential of murine hematopoietic stem cells is a rare property only partially predicted by phenotype

    Qinyu Zhang, Rasmus Olofzon ... David Bryder
    Application of a polyvinyl alcohol-based culture system reveals extensive differentiation but simultaneous robust murine hematopoietic stem cell (HSC) expansion, which are characterized by phenotypic, functional, and molecular properties shared with freshly isolated bone marrow HSCs.
    1. Stem Cells and Regenerative Medicine

    Computationally defined and in vitro validated putative genomic safe harbour loci for transgene expression in human cells

    Matias I Autio, Efthymios Motakis ... Roger SY Foo
    Depiction of novel human genomic safe harbour loci that have been validated in vitro for safety and stable expression in human embryonic stem cells and cell types from all the three germ lineages.
    1. Immunology and Inflammation
    2. Stem Cells and Regenerative Medicine

    Maresin 1 repletion improves muscle regeneration after volumetric muscle loss

    Jesus A Castor-Macias, Jacqueline A Larouche ... Carlos A Aguilar
    The treatment of injury from volumetric muscle loss with Maresin 1 reduces inflammation and fibrosis, driving improvements in the recovery of muscle strength.
    1. Stem Cells and Regenerative Medicine

    An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of amyotrophic lateral sclerosis

    J Barney Bryson, Alexandra Kourgiantaki ... Linda Greensmith
    Stem-cell-based neural replacement, in combination with optogenetic stimulation, could represent a translationally viable therapeutic strategy to overcome atrophy and paralysis of targeted muscles in people living with amyotrophic lateral sclerosis.