Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Pigment cell progenitor heterogeneity and reiteration of developmental signaling underlie melanocyte regeneration in zebrafish

    William Tyler Frantz, Sharanya Iyengar ... Craig J Ceol
    Zebrafish pigment cell progenitors are a heterogeneous class of adult tissue-resident cells which reiterate developmental signaling during melanocyte regeneration.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly

    Martin H Berryer, Gizem Rizki ... Lindy E Barrett
    An automated synaptic phenotyping platform combined with small molecule screening reveals modulators of human neuron synapse formation.
    1. Stem Cells and Regenerative Medicine

    Identification of phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow based on single-cell RNA sequencing

    Hongzhe Li, Sandro Bräunig ... Stefan Scheding
    Single-cell transcriptomic profiling of human bone marrow non-hematopoietic cells provides the basis for a comprehensive understanding of the cellular complexity of the hematopoietic stem cell (HSC) microenvironment and the intricate stroma-hematopoiesis crosstalk mechanisms.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export

    Yulong Qiao, Qiang Sun ... Huating Wang
    YTHDC1 is an essential factor controlling satellite cell regenerative ability through multifaceted gene regulatory mechanisms in myoblast cells.
    1. Stem Cells and Regenerative Medicine

    NFATc1 marks articular cartilage progenitors and negatively determines articular chondrocyte differentiation

    Fan Zhang, Yuanyuan Wang ... Xianpeng Ge
    NFATc1 is identified as a molecular marker of articular cartilage progenitor cells and a transcriptional repressor of chondrocyte differentiation, providing fundamental insights into the origin and differentiation mechanism of articular chondrocytes.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Articular Cartilage: Where it all started

    Long Zhang, Na Li, Ren Xu
    The progenitor cells that form articular cartilage express a gene for a protein called NFATc1, which stops articular chondrocytes from developing too early in the joint.
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    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Aggregating in vitro-grown adipocytes to produce macroscale cell-cultured fat tissue with tunable lipid compositions for food applications

    John Se Kit Yuen Jr, Michael K Saad ... David L Kaplan
    A simple way to create larger volumes of fat tissue for food purposes may be to grow individual fat cells and mechanically combine them together (rather than directly growing the full tissue).
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Lineage-specific differences and regulatory networks governing human chondrocyte development

    Daniel Richard, Steven Pregizer ... April M Craft
    The transcriptomic and epigenetic landscapes of developing human articular and growth plate cartilage reveal putative gene regulatory networks governing lineage commitment and tissue homeostasis.
    1. Stem Cells and Regenerative Medicine
    2. Developmental Biology

    Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids

    Jaydeep Sidhaye, Philipp Trepte ... Jürgen A Knoblich
    RNA-protein multiome approach helps to discover that the posttranscriptional regulation of the translational machinery is crucial for the fidelity of cortical development.
    1. Stem Cells and Regenerative Medicine

    Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

    Ece Yildiz, Gaby El Alam ... Kristina Schoonjans
    Chronic fat overload triggers the conversion of quiescent biliary epithelial cells into proliferative progenitors through an E2F-dependent mechanism.