Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Human spinal cord in vitro differentiation pace is initially maintained in heterologous embryonic environments

    Alwyn Dady et al.
    Comparison of human spinal cord rosette differentiation in vitro and following transplantation into heterologous embryonic environments, reveals cell-intrinsic constraint on human differentiation pace and the importance of timely extrinsic signalling for progression through an intrinsic human neural differentiation programme.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Paraxial mesoderm organoids model development of human somites

    Christoph Budjan et al.
    Human somites are formed in organoids from human pluripotent stem cells.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Temperature evolution following joint loading promotes chondrogenesis by synergistic cues via calcium signaling

    Naser Nasrollahzadeh et al.
    The loading-induced temperature evolution phenomenon in the knee joint modulates chondrogenic cells response to loading and accordingly opens a new paradigm that is coined 'thermo-mechanobiology'.
    1. Immunology and Inflammation
    2. Stem Cells and Regenerative Medicine

    Erythropoietin directly remodels the clonal composition of murine hematopoietic multipotent progenitor cells

    Almut S Eisele et al.
    Erythropoietin transiently remodels the hematopoietic stem and progenitor cells pool by directly inducing myeloid-erythroid-megakaryocyte-biased multipotent progenitor clones compensated at the population level by induction of myeloid-B-cell-dendritic-cell-biased clones.
    1. Stem Cells and Regenerative Medicine

    Induction of osteogenesis by bone-targeted Notch activation

    Cong Xu et al.
    Bone formation in adult mice can be induced by a bone-binding, recombinant version of the Notch ligand Delta-like 4 without triggering adverse effects in other organs.
    1. Stem Cells and Regenerative Medicine

    Kidney organoids recapitulate human basement membrane assembly in health and disease

    Mychel RPT Morais et al.
    Kidney organoids are a high-fidelity system for investigating basement membrane regulation in development and disease.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells

    Wai Hoe Ng et al.
    An induced pluripotent stem-cell-based, human heart and lung co-differentiation model reveals their shared signaling requirement and enables investigation of their developmental mutual interaction and tissue boundary formation.
    1. Immunology and Inflammation
    2. Stem Cells and Regenerative Medicine

    Hematopoietic stem and progenitor cells improve survival from sepsis by boosting immunomodulatory cells

    Daniel E Morales-Mantilla et al.
    Infusion of hematopoietic stem and progenitor cells rescues mice from lethal Group A streptococcal sepsis.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Transcriptional regulation of neural stem cell expansion in the adult hippocampus

    Nannan Guo et al.
    Kruppel-like factor 9 (Klf9) is a transcriptional regulator of neural stem cell expansion in the adult hippocampus.