Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium

    David W Wolfson, Joshua A Hull ... Kenneth D Poss
    Bioluminescence imaging in live mice was used to assess the abilities of systemically introduced adeno-associated viral capsids containing enhancer regulatory sequences to target transgene expression to myocardial injuries.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline

    Rui Feng, Sarah F Rosen ... Valeria Cavalli
    Inhibition of the endothelin B receptor (ETBR) with FDA-approved Bosentan enhances axon regeneration and reverses age-related decline, revealing a promising therapeutic target for improving nerve repair in older individuals.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Alteration of long- and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesis

    Katsuyuki Nishi, Taro Sakamaki ... Masanori Miyanishi
    Self-renewal heterogeneity causes myeloid skewing.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Efficient Generation of Expandable Dorsal Forebrain Neural Rosette Stem Cell Lines

    Signe Emilie Dannulat Frazier, Kristian Honnens de Lichtenberg ... J Carlos Villaescusa
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stochastic cell-intrinsic stem cell decisions control colony growth in planarians

    Tamar Frankovits, Prakash Varkey Cherian ... Omri Wurtzel
    Stochastic intrinsic fate decisions by planarian stem cells drive clonal expansion and reveal a straightforward, feedback‐independent mechanism for robust cell identity selection.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation

    Li He, Jiayu Wen, Qi Dai
    PRDM16 directs BMP signaling outcomes by guiding SMAD complex genomic binding to repress neural stem cell proliferation and promote choroid plexus epithelial specification.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Cardiac Repair: Aiming for spatial and temporal control of gene expression

    Stanislao Igor Travisano, Ching-Ling Lien
    Bioluminescent imaging is helping researchers better understand the effectiveness of tissue regeneration enhancers delivered to injured heart tissue by different adeno-associated virus vectors.
    Version of Record
    Insight
    1. Stem Cells and Regenerative Medicine

    CRISPR-edited DPSCs constitutively expressing BDNF enhance dentin regeneration in injured teeth

    Ji Hyun Kim, Muhammad Irfan ... Seung Chung
    Brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling in promoting the differentiation and dentin-repair capacity of dental stem cells under inflammatory conditions offers a potential clinical strategy for repairing damaged teeth.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma

    M Reza Bahranifard, Jessica Chan ... C Ross Ethier
    Magnetically steered mesenchymal stem cells significantly lowered intraocular pressure for 9 months in mice, motivating the translation of this technology for the treatment of glaucoma.
    1. Stem Cells and Regenerative Medicine

    PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification

    José Antonio Valer, Alexandre Deber ... Francesc Ventura
    PI3Kα inhibitors show promise as therapeutic agents for the treatment of heterotopic ossification.