Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Stem Cells and Regenerative Medicine

    Pharmacologically inducing regenerative cardiac cells by small molecule drugs

    Wei Zhou, Kezhang He ... Sheng Ding
    Induction of regenerative cardiac cells (RCCs) from human embryonic stem cell-derived cardiomyocytes and neonatal rat cardiomyocytes using a novel two-compound treatment enhances heart function following myocardial infarction and offers a promising avenue for cardiac regeneration through transcriptional and epigenetic reprogramming.
    1. Stem Cells and Regenerative Medicine

    Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration

    Simon Perrin, Maria Ethel ... Céline Colnot
    A single-nucleus atlas of bone repair uncovers the trajectories of periosteal skeletal stem/progenitor cells in response to fracture and identifies injury-induced fibrogenic cells as intermediate osteochondroprogenitors and key paracrine regulators.
    1. Stem Cells and Regenerative Medicine

    Dynamic tracking of native precursors in adult mice

    Suying Liu, Sarah E Adams ... Peter Kurre
    A revised analytical framework grounded in the principle of binomial distribution captures the full clonality and dynamic shifts of hematopoiesis throughout ontogeny.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Magnetically Steered Cell Therapy For Functional Restoration Of Intraocular Pressure Control In Open-Angle Glaucoma

    M Reza Bahrani Fard, Jessica Chan ... C Ross Ethier
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Modeling corticotroph deficiency with pituitary organoids supports the functional role of NFKB2 in human pituitary differentiation

    Thi Thom Mac, Teddy Fauquier ... Thierry Brue
    Pituitary organoids help identify NFKB2 as a new actor during pituitary development, and mutations of this gene as the cause for pituitary deficit observed in patients with DAVID syndrome.
    1. Stem Cells and Regenerative Medicine

    The Jag2/Notch1 signaling axis promotes sebaceous gland differentiation and controls progenitor proliferation

    Syeda Nayab Fatima Abidi, Sara Chan ... Christian W Siebel
    Inhibition of Notch signaling through the Jag2 ligand, blocks homeostatic sebocyte differentiation, and pushes the cells to a progenitor fate, in a reversible manner.
    1. Stem Cells and Regenerative Medicine

    Switching of RNA splicing regulators in immature neuroblasts during adult neurogenesis

    Corentin Bernou, Marc-André Mouthon ... François Dominique Boussin
    Characterization of an abundant clonogenic and multipotent population of immature neuroblasts, at the transition between transient-amplifying progenitor (TAP) neuroblasts and migratory neuroblasts, reversibly engaged in neuronal differentiation.
    1. Biochemistry and Chemical Biology
    2. Stem Cells and Regenerative Medicine

    Proteomic and functional comparison between human induced and embryonic stem cells

    Alejandro J Brenes, Eva Griesser ... Angus I Lamond
    Human induced pluripotent stem cells and embryonic stem cells express a similar set of proteins, but the levels of cytoplasmic and mitochondrial proteins vary, with concomitant effects on phenotypes including transport and mitochondrial function.
    1. Stem Cells and Regenerative Medicine

    Complete suspension culture of human induced pluripotent stem cells supplemented with suppressors of spontaneous differentiation

    Mami Matsuo-Takasaki, Sho Kambayashi ... Yohei Hayashi
    Adding suppressors of spontaneous differentiation enables precise control of human induced pluripotent stem cell (hiPSC) status in suspension culture conditions and leads to scalable and automated cell therapy using hiPSCs.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids

    Kyoung Jo, Zong-Yuan Liu ... Idse Heemskerk
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling