Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single Cell Transcriptomics-Informed Induced Pluripotent Stem Cells Differentiation to Tenogenic Lineage

    Angela Papalamprou, Victoria Yu ... Dmitriy Sheyn
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    1. Stem Cells and Regenerative Medicine

    Cell Death: Caspases promote cell proliferation after necrosis

    Prathibha Yarikipati, Andreas Bergmann
    An enzyme known as caspase, which initiates apoptosis, has a central role in the regeneration of cells and repair of tissue that can occur after necrosis.
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    1. Stem Cells and Regenerative Medicine

    Notch Signaling: Antibodies get under the skin

    Chiara Levra Levron, Gabriele Piacenti, Giacomo Donati
    By inhibiting receptor-ligand interactions in sebaceous glands, antibodies may be able to treat certain skin conditions.
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    1. Stem Cells and Regenerative Medicine

    Immune Cells: Growing microglia in the lab

    Jonathan M Levenson, Hio Tong Kam, Dong Feng Chen
    Transplanting microglia derived from human stem cells into mice reveals new possibilities for treating neurodegenerative eye diseases.
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    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Arp2/3 complex activity enables nuclear YAP for naïve pluripotency of human embryonic stem cells

    Nathaniel Paul Meyer, Tania Singh ... Diane L Barber
    Clonal naïve human embryonic stem cells assemble an Arp2/3 complex-dependent contractile actin filament ring around colonies that promotes tensional forces favoring cell-cell adhesion and nuclear translocation of YAP to maintain ground-state pluripotency.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Stem Cells: Don’t be so naïve

    Valerie Horsley, Aya Nassereddine
    New evidence sheds light on actin regulation of pluripotency in human embryonic stem cells.
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    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Delivery of a Jagged1-PEG-MAL hydrogel with pediatric human bone cells regenerates critically sized craniofacial bone defects

    Archana Kamalakar, Brendan Tobin ... Steven L Goudy
    Innovative JAGGED1-based therapies show promise for pediatric craniofacial bone loss, potentially overcoming limitations of current treatments with more effective and accessible solutions.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Negative cell cycle regulation by calcineurin is necessary for proper beta cell regeneration in zebrafish

    Laura Massoz, David Bergemann ... Isabelle Manfroid
    Calcineurin fine tunes the balance between proliferation and differentiation of Notch-responsive progenitors in the pancreatic ducts to enable beta cell regeneration in zebrafish.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis

    Kyusang Yoo, Young-Woo Jo ... Young-Yun Kong
    GDNF receptor-expressing mesenchymal progenitor subpopulation within skeletal muscle responds to peripheral nerve injury by sensing GDNF and secreting BDNF, thereby directly promoting nerve regeneration through facilitating remyelination by Schwann cells.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Reprogramming: A perfect recipe for a corticospinal neuron

    Alfonso Aguilera, Marta Nieto
    A tailored cocktail of genes can reprogram a subset of progenitors to no longer produce glial cells and instead develop into neurons involved in motor control.
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