Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiation

    Francisco X Galdos, Carissa Lee ... Sean M Wu
    TBX5 lineage tracing and high resolution single cell transcriptomics uncover the predominance of first heart field development during human-induced pluripotent stem cell cardiac differentiation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Cardiac Development: Tracing the history of a heart

    Brian Spurlock, Li Qian
    Newly developed tools will help researchers understand how the human heart develops and build better models to study and treat congenital heart disease.
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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Low-level repressive histone marks fine-tune gene transcription in neural stem cells

    Arjun Rajan, Lucas Anhezini ... Cheng-Yu Lee
    Stem-cell-specific transcriptional repressors fine-tune levels of stemness gene transcripts in asymmetrically dividing neural stem cells by depositing low levels of repressive histone marks at these loci allowing progeny to rapidly initiate differentiation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Haploinsufficiency of the essential gene Rps12 causes defects in erythropoiesis and hematopoietic stem cell maintenance

    Virginia Folgado-Marco, Kristina Ames ... Nicholas E Baker
    The homozygous and heterozygous phenotypes of mouse Rps12 deletion are described, highlighting pancytopenia reflecting roles in hematopoiesis and erythropoiesis.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Cell-free DNA as a potential biomarker of differentiation and toxicity in cardiac organoids

    Brian Silver, Kevin Gerrish, Erik Tokar
    Cardiac organoids have potential as a tool used for identifying cell-free DNA as biomarkers for toxicity and severity of exposure outcomes.
    1. Stem Cells and Regenerative Medicine

    Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

    Yaeko Nakajima-Takagi, Motohiko Oshima ... Atsushi Iwama
    Polycomb repressive complex 1.1 restricts precocious myeloid differentiation of hematopoietic stem/progenitor cells and expansion of myeloid progenitors, thereby serving as a gatekeeper of emergency myelopoiesis and myeloid transformation.
    1. Stem Cells and Regenerative Medicine

    Comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'

    Anne Sustar, John C Tuthill
    We are writing to comment on the article by Abrams et al., 2021 about appendage regeneration in jellyfish, fruit flies, and mice.
    1. Evolutionary Biology
    2. Stem Cells and Regenerative Medicine

    Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'

    Yutian Li, Anish A Sarma ... Lea Goentoro
    We are writing to respond to the comment by Sustar and Tuthill, 2023 on our article about appendage regeneration in jellyfish, fruit flies, and mice (Abrams et al., 2021).
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Brain Development: The dangers of rubella virus

    Ekaterina Epifanova, Laurent Nguyen
    The rubella virus can interfere with fetal brain development by infecting immune cells called microglia during pregnancy.
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    1. Stem Cells and Regenerative Medicine

    Inhibition of type I PRMTs reforms muscle stem cell identity enhancing their therapeutic capacity

    Claudia Dominici, Oscar D Villarreal ... Stéphane Richard
    Inhibition of type I PRMTs increases the proliferation capabilities of MuSCs with altered cellular metabolism, while maintaining their stem-like properties such as self-renewal and engraftment potential.