Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Stem Cells and Regenerative Medicine

    Hippo signaling impairs alveolar epithelial regeneration in pulmonary fibrosis

    Rachel Warren, Handeng Lyu ... Stijn P De Langhe
    Alveolar type 2 stem cells are actively maintained by Hippo signaling and Taz promotes alveolar epithelial regeneration and the resolution of bleomycin induced pulmonary fibrosis upon inactivation of the Hippo pathway in Alveolar type 2 stem cells.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation

    Rafael Soares Godoy, Nicholas D Cober ... Duncan J Stewart
    Single-cell transcriptomic analysis reveals novel regenerative endothelial cell populations that mediate remarkably rapid and complete microvascular repair in a novel model of acute lung injury induced by endothelial cell ablation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell transcriptomics of a dynamic cell behavior in murine airways

    Sheldon JJ Kwok, Daniel T Montoro ... Vladimir Vinarsky
    Live imaging of cells in an intact murine tissue combined with single-cell sequencing reveals a unique transcriptional signature of an observed cellular behavior.
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    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner

    Hanghang Liu, Akane Wada ... Clifford J Rosen
    Loss or PTH1R-mediated repression of Zfp467 results in a pathway that increases Pth1r transcription via NFκB1 and thus cellular responsiveness to PTH/PTHrP, ultimately leading to enhanced bone formation.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    CHD-associated enhancers shape human cardiomyocyte lineage commitment

    Daniel A Armendariz, Sean C Goetsch ... Gary C Hon
    Single-cell screens during human cardiomyocyte (CM) differentiation reveal that perturbation of congenital heart defect-linked enhancers/genes causes deficient CM differentiation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Pigment cell progenitor heterogeneity and reiteration of developmental signaling underlie melanocyte regeneration in zebrafish

    William Tyler Frantz, Sharanya Iyengar ... Craig J Ceol
    Zebrafish pigment cell progenitors are a heterogeneous class of adult tissue-resident cells which reiterate developmental signaling during melanocyte regeneration.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly

    Martin H Berryer, Gizem Rizki ... Lindy E Barrett
    An automated synaptic phenotyping platform combined with small molecule screening reveals modulators of human neuron synapse formation.
    1. Stem Cells and Regenerative Medicine

    Identification of phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow based on single-cell RNA sequencing

    Hongzhe Li, Sandro Bräunig ... Stefan Scheding
    Single-cell transcriptomic profiling of human bone marrow non-hematopoietic cells provides the basis for a comprehensive understanding of the cellular complexity of the hematopoietic stem cell (HSC) microenvironment and the intricate stroma-hematopoiesis crosstalk mechanisms.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export

    Yulong Qiao, Qiang Sun ... Huating Wang
    YTHDC1 is an essential factor controlling satellite cell regenerative ability through multifaceted gene regulatory mechanisms in myoblast cells.
    1. Stem Cells and Regenerative Medicine

    NFATc1 marks articular cartilage progenitors and negatively determines articular chondrocyte differentiation

    Fan Zhang, Yuanyuan Wang ... Xianpeng Ge
    NFATc1 is identified as a molecular marker of articular cartilage progenitor cells and a transcriptional repressor of chondrocyte differentiation, providing fundamental insights into the origin and differentiation mechanism of articular chondrocytes.
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