Browse our latest Structural Biology and Molecular Biophysics articles

Molecular simulations can capture key aspects of the conformational exchange in a protein.

A cryo-electron microscopy model of the active human apoptosome illuminates how this "wheel of death" binds the protease procaspase-9 to initiate programmed cell death.

Crystal structures of synaptic recognition molecules Sidekick-1 and -2 reveal a single homodimer interaction mode responsible for both cell-cell recognition and cis-clustering, suggesting that competition between cis and trans interactions may be critical to specificity.

The structural and functional analysis demonstrates the mechanism of dual functional, motility and microtubule depolymerization in a unique motor, KIF19A.

Biophysical and biochemical approaches reveal new insights into the architecture of CAF-1 and the unique mechanism by which CAF-1 tetramerizes histones H3/H4.

Different combinations of the transcription factors Pou5f3, Nanog and Sox32 form complexes to drive dorsoventral mesendoderm patterning in zebrafish.

The crystal structure of human Holliday junction resolvase GEN1 in complex with DNA reveals a conserved chromodomain as an additional DNA-anchoring point that opens new perspectives for enzyme regulation.

Simulations of molecular dynamics suggest how the binding of the β-grasp domain of SUMO1 induces conformational and dynamic effects to activate SENP1.

DNA unwinding triggers a conformational change in the RecD subunit of E. coli RecBCD helicase-nuclease that is transferred through the RecC subunit to activate the nuclease domain of the RecB subunit.

Computations based on detailed atomic models explain how the ATP-driven sodium-potassium pump avoids transporting the wrong type of ions in order to maintain the physiological concentration of sodium and potassium ions across the cell membrane.