Browse our latest Structural Biology and Molecular Biophysics articles

The bacterial cytolysin synthetase CylM has a eukaryotic lipid kinase fold despite the absence of any clear sequence similarity, and contains adjacent phosphorylation and phosphate elimination active sites and an ordered activation loop in the absence of peptide substrate or regulatory proteins.

Structure/function studies of a plant pathogen effector in complex with a host disease resistance protein domain reveal the molecular basis for recognition and underpin future engineering of immunity in crops.

CLR01 is a small molecule that could be an effective topical microbicide to eliminate HIV (and other enveloped viruses), and to antagonize host-encoded amyloid fibrils that promote HIV infection.

Soluble αβ-tubulin assembly is regulated by a cage-like molecular complex containing tubulin cofactors and Arl2.

Binding of STIL to PLK4's characteristic Polo-box 3 links PLK4 kinase activation to STIL self-association and is a crucial regulatory step for the localized recruitment of downstream factors in centriole duplication.

The number of contacts at the interface of a protein–protein complex, together with the properties of the surface, provides a simple, but well-performing predictor of binding affinity.

Atomic structures suggest a novel mechanism for the regulation of mRNA transcription and capping in dsRNA viruses.

Visualization of the sliding clamp in DNA mismatch repair shows how a transient complex is activated.

Structural and functional analyses show how the spliceosomal Prp3 protein concomitantly binds double- and single- stranded regions in U4/U6 di-snRNAs and serves to stabilize the U4/U6•U5 tri-snRNP for splicing.

Lys63-linked diubiquitin exists as an ensemble of conformational states, each responsible for binding to a target protein through conformational selection.