Browse our latest Structural Biology and Molecular Biophysics articles

Page 154 of 186
    1. Structural Biology and Molecular Biophysics

    Cryo-EM single particle analysis with the Volta phase plate

    Radostin Danev, Wolfgang Baumeister
    The Volta phase plate enables in-focus single particle analysis at near atomic resolutions, which could expand the capabilities of cryo-EM, especially for small, flexible or heterogeneous macromolecular samples.
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission

    Julia Santiago, Benjamin Brandt ... Michael Hothorn
    A plant peptide hormone controls organ shedding by acting as molecular glue that promotes the interaction between two membrane receptor kinases.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A bacteriophage endolysin that eliminates intracellular streptococci

    Yang Shen, Marilia Barros ... Daniel C Nelson
    Unlike other similar enzymes, the antimicrobial enzyme PlyC can interact with and translocate eukaryotic membranes, and then lyse and kill intracellular bacteria.
    1. Structural Biology and Molecular Biophysics

    Structural basis for DNA 5´-end resection by RecJ

    Kaiying Cheng, Hong Xu ... Yuejin Hua
    A structural investigation reveals details of the mechanism by which the nuclease RecJ processes DNA ends to repair double strand breaks.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The structure of the core NuRD repression complex provides insights into its interaction with chromatin

    Christopher J Millard, Niranjan Varma ... John WR Schwabe
    An extensive interface between the proteins RBBP4 and MTA1 defines the three-dimensional architecture of the core NuRD complex and determines the recruitment of the complex to chromatin.
    1. Structural Biology and Molecular Biophysics

    Pre-transition effects mediate forces of assembly between transmembrane proteins

    Shachi Katira, Kranthi K Mandadapu ... David Chandler
    A general mechanism for how powerful forces of assembly and protein mobility can emerge from phase transitions is established.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Time-resolved multimodal analysis of Src Homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases

    Joshua A Jadwin, Dongmyung Oh ... Bruce J Mayer
    The recruitment of SH2-containing proteins to Epidermal Growth Factor in cells happens more slowly than predicted by in vitro techniques.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    VEGFR-2 conformational switch in response to ligand binding

    Sarvenaz Sarabipour, Kurt Ballmer-Hofer, Kalina Hristova
    A receptor for vascular endothelial growth factor forms dimers in the absence of its ligand, and ligand-binding leads to structural changes that result in increased kinase phosphorylation.