Browse our latest Structural Biology and Molecular Biophysics articles

Correlated mutation analysis using a combination of amino acid and codon sequence alignments improves predictions of amino acid residue contacts in proteins.

New labeling approaches for single-molecule fluorescence microscopy detect the monomeric catalytic subunit of human telomerase within cellular holoenzyme and minimal active recombinant enzyme.

Some nuclear export signals (NESs) bind to the transport receptor CRM1 in the opposite orientation to those previously studied.

The crystal structure of Thermus transcription activation complexes containing the transcriptional activator CarD reveals a new mechanism for the activation of transcription.

The crystal structure of bacterial RNA polymerase bound to the transcription bubble reveals key features that support the formation of a double-strand/single-strand DNA junction at the upstream edge of the −10 element where bubble formation initiates.

Single-molecule force and fluorescence spectroscopy reveal the structural states and dynamics of E. coli single-stranded DNA binding proteins and the energy landscape of the nucleo–protein complex.

The ligand-binding pocket of the Dishevelled PDZ domain can be occupied by Dishevelled's own highly conserved C-terminus, inducing a closed conformation that is ‘opened’ when Wnt signaling stimulates interaction between Frizzled and Dishevelled.

The Chip/LDB-SSDP complex integrates multiple signals to render TCF/LEF enhancers Wnt responsive.

A structural analysis of the transcription regulator Mot1 in complex with promoter DNA and the proteins TBP and NC2 provides a first structural framework for how a Swi2/Snf2 type remodeler interacts with a histone fold protein:DNA complex.

Rare mutations in the switch III region of Ras can increase its nanoscale clustering, which enhances effector recruitment and downstream signaling.