Browse our latest Structural Biology and Molecular Biophysics articles

Laboratory-based methods are presented that produce filamentous tau aggregates with the same structures as those observed in neurodegenerative disease.

Structures of PKA in complex with wild type and mutant phospholamban show a mechanism underlying familial dilated cardiomyopathy.

Computer simulations explore the experimentally unknown S-protein structures, revealing novel drug binding sites.

The function of the SARS-CoV-2 spike is controlled by allosterically modulating the dynamics of the receptor-binding domain.

Cryo-electron microscopy structures of full-length P5CS, the proline synthesis enzyme, reveal that filamentation is crucial for the coordinated catalytic reactions between the glutamate kinase and γ-glutamyl phosphate reductase domains.

A cargo recognition α-helix was identified in Nup358, which is required for activation of a dynein-dependent transport pathway that is essential for brain development.

STIM1 regulates the contractility of blood vessels and blood pressure by organizing membrane contact sites and ion channel activity in vascular smooth muscle cells in a manner that is independent of its canonical function in store-operated Ca²⁺entry.

Cryogenic electron microscopy of the ryanodine receptor 1 at near-atomic resolution reveals a calcium-inactivated conformation and uncovers a conserved lipid-binding site.

The protein STIM1 helps to maintain membrane coupling sites in smooth muscle cells that regulate arterial contractility and blood pressure.

Flow stimulates PC-1/PC-2 clusters in the plasma membrane of endothelial cells, leading to Ca²⁺ influx, NOS, SK channel, and IK channel activation, vasodilation, and a reduction in blood pressure.