Browse our latest Structural Biology and Molecular Biophysics articles

Page 7 of 180
    1. Structural Biology and Molecular Biophysics

    LC8 enhances 53BP1 foci through heterogeneous bridging of 53BP1 oligomers

    Jesse Howe, Douglas Walker ... Elisar J Barbar
    The oligomerization domain of 53BP1, a key DNA repair protein, is a trimer which binds the dimeric hub protein LC8 by a novel mechanism to form dynamic heterogeneous complexes.
    1. Structural Biology and Molecular Biophysics

    Martinize2 and Vermouth: Unified Framework for Topology Generation

    Peter C Kroon, Fabian Grunewald ... Siewert-Jan J Marrink
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

    Roman O Fedoryshchak, Karim El-Bouri ... Richard Treisman
    Proteomics with PP1-Neurabin fusion proteins identify the 4E-BP proteins as novel Neurabin/PP1 substrates, and interaction with the Neurabin PDZ domain shown to be the major determinant of Neurabin/PP1 substrate specificity.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Mapping HIV-1 RNA structure, homodimers, long-range interactions and persistent domains by HiCapR

    Yan Zhang, Jingwan Han ... Zhihu Zhao
    HiCapR uncovers HIV RNA homodimers and long-range interactions that show structural dynamics critical for viral packaging and assembly.
    1. Structural Biology and Molecular Biophysics

    Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases

    Jianing Liu, Anokhi Shah ... Keni Vidilaseris
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    The Structural Dynamics of IRE1 and its Interaction with Unfolded Peptides

    Elena Spinetti, G Elif Karagöz, Roberto Covino
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structure of an oxygen-induced tubular nanocompartment in Pyrococcus furiosus

    Wenfei Song, Jan Fiala ... Friedrich Förster
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1

    Jing Xue, Weizhong Zeng ... Youxing Jiang
    Cryo-EM structures of HsNCX1 in complex with either phosphatidylinositol 4,5-bisphosphate (a physiological activator) or SEA0400 (a pharmacological inhibitor) provide mechanistic insights into the cellular regulation and pharmacology of NCX proteins.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Reliable protein–protein docking with AlphaFold, Rosetta, and replica exchange

    Ameya Harmalkar, Sergey Lyskov, Jeffrey J Gray
    New protein-protein docking algorithm combining deep learning (AlphaFold2) and physics (Rosetta and enhanced sampling) achieves high success rates.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers

    Robert G Stewart, Matthew James Marquis ... Jon T Sack
    Drugs are identified that unmask molecular origins of certain neuronal potassium currents, enabling functional analysis of previously indistinguishable potassium channel subtypes.
Newer articles Older articles