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    1. Structural Biology and Molecular Biophysics

    Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

    Jordan M Mancl, Wenguang G Liang ... Wei-Jen Tang
    Not revised
    Reviewed Preprint v1
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    • Convincing
    1. Structural Biology and Molecular Biophysics

    The mechanism of DRB7.2:DRB4 mediated sequestering of endogenous inverted-repeat dsRNA precursors in plants

    Sneha Paturi, Debadutta Patra ... Mandar V Deshmukh
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    AI-based discovery and cryoEM structural elucidation of a KATP channel pharmacochaperone

    Assmaa Elsheikh, Camden M Driggers ... Show-Ling Shyng
    Structure-based approach identifies a KATP-binding compound that has the potential of normalizing insulin secretion in congenital hyperinsulinism by correcting defective KATP channel trafficking to the cell surface.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Microphase separation produces interfacial environment within diblock biomolecular condensates

    Andrew P Latham, Longchen Zhu ... Bin Zhang
    The microenvironment within biomolecular condensates exhibits interfacial behaviors characterized by a combination of hydrophobic and hydrophilic properties.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Genomic and structural insights into Jyvaskylavirus, the first giant virus isolated from Finland

    Gabriel Magno de Freitas Almeida, Iker Arriaga ... Lotta-Riina Sundberg
    Jyvaskylavirus, the northernmost isolate of the Marseilleviridae family, shows that giant viruses are also part of the boreal Finnish environment and brings structural information with relevance for understanding other viruses.
    1. Structural Biology and Molecular Biophysics
    2. Cancer Biology

    A role for JAK2 in mediating cell surface GHR-PRLR interaction

    Chen Chen, Jing Jiang ... André Leier
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution

    Adrián Merino-Salomón, Jonathan Schneider ... Germán Rivas
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm

    Marta Wojnowska, Takeaki Wajima ... Ulrich Schwarz-Linek
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Elucidating the Mechanism Underlying UBA7•UBE2L6 Disulfide Complex Formation

    Pei-Tzu Chen, Jia-Yin Yeh ... Kuen-Phon Wu
    Not revised
    Reviewed Preprint v1
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    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Electrostatics of salt-dependent reentrant phase behaviors highlights diverse roles of ATP in biomolecular condensates

    Yi-Hsuan Lin, Tae Hun Kim ... Hue Sun Chan
    A combination of polymer physics theories consistently rationalizes comprehensive experimental effects of salt, ATP, phosphorylation, and sequence charge and arginine/lysine patterns on the reentrant phase behaviors of intrinsically disordered proteins.
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