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    1. Structural Biology and Molecular Biophysics

    Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX

    Aivaras Vaškevičius, Denis Baronas ... Daumantas Matulis
    A series of compounds were synthesized and demonstrated to form a specific covalent bond with His64 of CAIX, an anticancer target, a strategy applicable to any drug design project.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Control of 3′ splice site selection by the yeast splicing factor Fyv6

    Katherine A Senn, Karli A Lipinski ... Aaron A Hoskins
    The Saccharomyces cerevisiae spliceosome component Fyv6 contributes to precursor messenger RNA splicing by promoting use of branch site distal 3' splice sites and interacting with key factors involved in exon ligation.
    1. Structural Biology and Molecular Biophysics

    Isoleucine gate blocks K+ conduction in C-type inactivation

    Werner Treptow, Yichen Liu ... Benoit Roux
    The conformation of an isoleucine gate located along the TM6 segment on the intracellular side below the selectivity filter is a critical component leading to a non-conductive state in the C-type inactivation process of K+ channels.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Effects of residue substitutions on the cellular abundance of proteins

    Thea K Schulze, Kresten Lindorff-Larsen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    Structure of the human CTF18 clamp loader bound to PCNA

    Giuseppina R Briola, Muhammad Tehseen ... Alfredo De Biasio
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    Ligand-coupled conformational changes in a cyclic nucleotide-gated ion channel revealed by time-resolved transition metal ion FRET

    Pierce Eggan, Sharona E Gordon, William N Zagotta
    Time-resolved tmFRET revealed structural and energetic changes induced by ligand binding with full agonist cAMP and partial agonist cGMP in the cyclic nucleotide-binding domain of the bacterial ion channel SthK.
    1. Structural Biology and Molecular Biophysics

    Protonation/deprotonation-driven switch for the redox stability of low-potential [4Fe-4S] ferredoxin

    Kei Wada, Kenji Kobayashi ... Masaki Unno
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Structural Biology and Molecular Biophysics

    A cryo-electron tomography study of ciliary rootlet organization

    Chris van Hoorn, Andrew P Carter
    Cryo-electron tomography uncovers the flexible, filamentous architecture of mouse ciliary rootlets and their regular cross-striations with extensive membrane connections.
    1. Structural Biology and Molecular Biophysics
    2. Evolutionary Biology

    Prebiotic Gas Flow Environment Enables Isothermal Nucleic Acid Replication

    Philipp Schwintek, Emre Eren ... Dieter Braun
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases

    Jianing Liu, Anokhi Shah ... Keni Vidilaseris
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
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