Browse our latest Structural Biology and Molecular Biophysics articles

Three newly developed biosensors demonstrate that the C-terminal tail of α-tubulin does not freely extend from the microtubule surface as widely thought, but rather is inaccessible along most microtubules in cells.

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.

Reducing the echo time of a whole-body MRI scanner makes it possible to image collagen, an important structural protein found in bones and tendons.

Intrinsic conformational flexibility of a solute transporter is restrained by substrates, resulting in Na+ allosterically enhancing primary substrate binding through cooperative constraints on the dynamics of the cytoplasmic inner barrier.

A novel F-actin-binding motif consisting of an α-helix hairpin from a Legionella pneumophila lysine fatty acyltransferase has the potential to be developed as an F-actin probe.

Covalent PPARγ inhibitors that better stabilize a repressive conformation are more effective inhibitors, but structural plasticity still allows ligand cobinding by enabling a shift back to an active conformation.

Clinically relevant Ω-loop mutations in PDC-3 reshape active-site dynamics to enhance β-lactamase activity, providing mechanistic insights that can guide the rational design of inhibitors.