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Dual blocking SHP2 and FGFR2 can not only promote the targeted tumor-killing effects and overcome FGFR2 inhibitor resistance caused by feedback activation, but also activate T cell-mediated anti-tumor immunity.

Inactivation of beta 1,4-galactosyltransferase 1 leads to enhanced T-cell receptor activation and CD8⁺ T-cell function by affecting the galactosylation of T-cell receptor and CD8.

Unique extracellular vesicle microRNA signatures resulting from G protein-coupled receptor activation indicate distinct downstream signaling and functional networks by receptor, with implications for developing new drugs and understanding their long-term and off-target effects.

Studying the reproductive life history of an acoel reveals that a body-size-dependent program regulates organ growth and regeneration dynamics and discovers a novel form of egg-laying behavior.

Competition between Quaking and SF1 for a subset of ACUAA intron branch sites influences alternative splicing in different tissues and organisms.