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    1. Immunology and Inflammation

    Ly6G+ granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

    Priya Sharma, Raman Deep Sharma ... Dhiraj Kumar
    The IL-17–Ly6G⁺ granulocyte axis is a key driver and correlate of tuberculosis pathology and represents a potential target for improving vaccine-induced protection and therapeutic outcomes.
    1. Cell Biology
    2. Neuroscience

    AutoMorphoTrack: A modular framework for quantitative analysis of organelle morphology, motility, and interactions at single-cell resolution

    Armin Bayati, Jackson G Schumacher, Xiqun Chen
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Decoding state specific connectivity during speech production and perception

    Yasamin Esmaeili, Amirhossein Khalilian-Gourtani ... Adeen Flinker
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience
    2. Evolutionary Biology

    Complex environmental cycles reveal evolution of circadian activity waveform and thermosensitive timeless splicing

    Pragya Niraj Sharma, Vasu Sheeba
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Developmental Biology
    2. Genetics and Genomics

    Single-cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location

    Joyner Cruz, William Y Sun ... Iswar K Hariharan
    Even in a simple epithelial tissue that is exposed uniformly to X-ray irradiation, cells show marked differences in their transcriptional response based on their location and cell-cycle status.
    1. Developmental Biology

    Jam2 Signaling Functions Downstream of Hand2 To Initiate The Formation Of Organ-Specific Vascular Progenitors In Zebrafish

    Martyna Griciunaite, Julius Martinkus ... Saulius Sumanas
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Improved sensory representations as a result of temporal adaptation

    Amber Marijn Brands, Zilan Oz ... Iris Isabelle Anna Groen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Multi-Scale Anti-Correlated Neural States Dominate Naturalistic Whole-Brain Activity

    Dora Gözükara, Djamari Oetringer ... Linda Geerligs
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Cancer Biology

    Repression of PRMT activities sensitize human homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

    Youyou Zhang, Mu Xu ... Xiaowen Hu
    Inhibiting PRMT1 and PRMT5 renders HR-proficient ovarian and breast cancers highly vulnerable to PARP inhibition by suppressing BRCAness and amplifying DNA-damage-driven innate immune signaling.
    1. Chromosomes and Gene Expression

    The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements

    Andria Koulle, Oluwaseun Ogundele ... Brian Hendrich
    CHD4 directly limits transcription factor binding to chromatin, which prevents activation of silent or cryptic enhancers but facilitates activity of active enhancers.
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