Browse our latest research

Page 172 of 1,897
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A systematic bi-genomic split-GFP assay illuminates the mitochondrial matrix proteome and protein targeting routes

    Yury S Bykov, Solene Zuttion ... Maya Schuldiner
    Combined with high-throughput yeast genetics, a split green fluorescent protein encoded directly in the mitochondrial DNA helps to identify targeting signals and functions of dually localized proteins.
    1. Neuroscience

    Dissociable memory modulation mechanisms facilitate fear amnesia at different timescales

    Yinmei Ni, Ye Wang ... Jian Li
    The retrieval-extinction paradigm elicits a short-term fear amnesia that differs in cue specificity, timescale, and dependence on thought-control ability from the long-term amnesia believed to be associated with memory reconsolidation.
    1. Genetics and Genomics

    Chromatin accessibility variation provides insights into missing regulation underlying immune-mediated diseases

    Raehoon Jeong, Martha L Bulyk
    Analyzing population-level chromatin accessibility data shows added benefit over utilizing only gene expression data in elucidating the genetic mechanism of disease-associated variants.
    1. Immunology and Inflammation
    2. Stem Cells and Regenerative Medicine

    IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion

    Daniel L Aldridge, Zachary Lanzar ... Christopher A Hunter
    Functional analyses showcase that in the absence of IL-27, hematopoietic stem and progenitor cells are more likely to become monocytes during toxoplasmosis, making them less responsive after infection.
    1. Neuroscience

    Early changes in the properties of CA3 engram cells explored with a novel viral tool in mice

    Dario Cupolillo, Noelle Grosjean ... Christophe Mulle
    A novel viral tool (FLEN) is designed, and used to monitor changes in the intrinsic and synaptic properties of engram cells quickly (3–6 hours) following encoding of a memory.
    1. Neuroscience

    Reactivation-coupled brain stimulation enables complete learning generalization

    Yibo Xie, Minmin Wang ... Ke Jia
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Spectral decomposition of local field potentials uncovers frequency-tuned gain modulation of working memory in primate visual system

    Majid Roshanaei, Mohammad Reza Daliri ... Behrad Noudoost
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Virtual Brain Inference (VBI), a flexible and integrative toolkit for efficient probabilistic inference on whole-brain models

    Abolfazl Ziaeemehr, Marmaduke Woodman ... Meysam Hashemi
    The Virtual Brain Inference (VBI) toolkit enables efficient, accurate, and scalable Bayesian inference over whole-brain network models, improving parameter estimation, uncertainty quantification, and predictive modeling across neuroimaging modalities toward precision medicine.
    1. Neuroscience

    Separating the control of moving and holding in human post-stroke arm paresis

    Alkis M Hadjiosif, Kahori Kita ... John W Krakauer
    Patients with stroke often show impairment in both moving and holding the arm, deficits that are dissociable experimentally, suggesting that moving and holding are controlled by separate neural mechanisms.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

    Naphannop Sereesongsaeng, Carole Bataille ... Terence Rabbitts
    Antibody surrogate degraders of LMO2 indicate that transcription complexes are susceptible to drug discovery and are therefore druggable.