Extracellular adenosine deamination by ADGF generates ammonia that directs tip organizer development, revealing a conserved metabolic mechanism linking nucleotide turnover to developmental regulation.
Genes steadily associated with prognosis define conserved mitotic and immune programs that robustly predict cancer patient survival and therapeutic resistance across tumor types.
Lauren Thornton, Taylor Dick ... Christofer J Clemente
Postural adjustments that reduce ankle leverage in kangaroos enhance tendon stress and elastic energy storage at higher speeds, providing energetic efficiency during hopping but potentially constraining the maximum size achievable by large species.
Distinct transcriptional subtypes in PPGLs link molecular programs with immune context, providing biomarkers for recurrence risk and therapeutic targeting.
Francine C Cadoná, Thais F Bartelli ... Emmanuel Dias-Neto
Elevated gfDNA supports gastric cancer diagnosis and may guide management when combined with tissue biopsies, and in established cancer, higher gfDNA may predict better outcomes, potentially indicating immune-cell infiltration.
Ana Dorrego-Rivas, Darren J Byrne ... Matthew S Grubb
Different locations of neurotransmitter release sites in axon-bearing and anaxonic olfactory bulb dopaminergic neurons allow self-inhibition only in anaxonic cells, showing how polarity differences create separate functional roles in sensory processing.
Anna Fijarczyk, Pauline Hessenauer ... Christian R Landry
A genomic analysis shows that the evolution of genome size and gene content among fungal pathogens in the class Sordariomycetes varies depending on their interactions with hosts and vectors.
Pyruvate dictates redox balance and cell size, establishing metabolism as a dominant regulator of cellular fitness, unveiling new strategies to modulate cancer, regeneration, and diabetes.
