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    1. Neuroscience

    Shortcutting from self-motion signals reveals a cognitive map in mice

    Jiayun Xu, Mauricio Girardi-Schappo ... Leonard Maler
    Mice can use self-motion cues to learn a cognitive map thereby permitting them to take shortcut trajectories in an open maze without requiring prior experience of such routes.
    1. Developmental Biology
    2. Ecology

    Body mass and growth rates predict protein intake across animals

    Stav Talal, Jon F Harrison ... Arianne J Cease
    Protein nutritional requirements decrease predictively with mass throughout ontogeny across the animal kingdom.
    1. Neuroscience

    Hypothalamic corticotropin-releasing hormone neurons modulate sevoflurane anesthesia and the post-anesthesia stress responses

    Shan Jiang, Lu Chen ... Chang-Rui Chen
    Discovery of critical brain nodes explaining how sevoflurane-induced general anesthesia works and how the post-anesthesia stress responses appear.
    1. Developmental Biology

    The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression patterns through regulation of WDR5 stability

    Huishan Wang, Xingyan Liu ... Pengcheng Ma
    The protein stability of WDR5, the core component of TrxG complex, is controlled by the ubiquitin ligase RNF220, which involves in the maintenance of Hox patterns in mouse hindbrain.
    1. Neuroscience

    A distributed brain response predicting the facial expression of acute nociceptive pain

    Marie-Eve Picard, Miriam Kunz ... Pierre Rainville
    Facial expression provides a complementary channel to communicate pain experiences and reflects the activation of brain mechanisms partly distinct from those associated with subjective self-reports of pain.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Biochemistry and Chemical Biology

    Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays

    Jonathan G Van Vranken, Jiaming Li ... Devin K Schweppe
    An approachable framework for the scalable implementation of proteome-wide thermal shift assays to assess drug mechanisms of action.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Exposure to live saprophytic Leptospira before challenge with a pathogenic serovar prevents severe leptospirosis and promotes kidney homeostasis

    Suman Kundu, Advait Shetty, Maria Gomes-Solecki
    Potential commensalism between saprophytic and pathogenic Leptospira within a vertebrate host protects against severe leptospirosis and improves kidney homeostasis which helps Leptospira interrogans complete its enzootic cycle.
    1. Computational and Systems Biology
    2. Cancer Biology

    BEHAV3D Tumor Profiler to map heterogeneous cancer cell behavior in the tumor microenvironment

    Emilio Rios-Jimenez, Anoek Zomer ... Maria Alieva
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging neurons

    Mofida Abdelmageed, Premkumar Palanisamy ... Anirban Paul
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids

    Kyoung Jo, Zong-Yuan Liu ... Idse Heemskerk
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling