Browse our latest research

Page 260 of 1,751
    1. Medicine
    2. Computational and Systems Biology

    Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning

    Gitanjali Roy, Rameesha Syed ... Michael A. Kalwat
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Fitness landscape of substrate-adaptive mutations in evolved amino acid-polyamine-organocation transporters

    Foteini Karapanagioti, Úlfur Águst Atlason ... Sebastian Obermaier
    Secondary active transporters can evolve to accommodate a broader range of substrates without losing their original substrate specificities.
    1. Neuroscience

    Reconfigurations of cortical manifold structure during reward-based motor learning

    Qasem Nick, Daniel J Gale ... Jason Gallivan
    Dimensionality reduction approaches on functional MRI data reveal that human reward-based motor learning emerges from dynamic changes in functional brain network interactions among sensorimotor, attention, and default mode networks.
    1. Developmental Biology

    Obox4 promotes zygotic genome activation upon loss of Dux

    Youjia Guo, Tomohiro Kitano ... Haruhiko Siomi
    Analysis of mouse zygotic genome activation (ZGA) reveals that a mis-annotated multicopy homeobox gene Obox4 functions redundantly with Dux to promote ZGA.
    1. Neuroscience

    Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus

    Eugene Gil, Sung Jun Hong ... Daniel A. Lim
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Fast burst fraction transients convey information independent of the firing rate

    Richard Naud, Xingyun Wang ... Guy Doron
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology
    2. Medicine

    The vaginal immunoproteome for the prediction of spontaneous preterm birth: A retrospective longitudinal study

    Zachary Shaffer, Roberto Romero ... Nardhy Gomez-Lopez
    The vaginal immunoproteome in pregnancy is more predictive of spontaneous preterm birth (sPTB) than maternal characteristics alone, with sPTB cases showing heightened pro-inflammatory profiles accompanied by reduced levels of antimicrobial proteins/peptides.
    1. Biochemistry and Chemical Biology

    Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry

    Laurie Peverini, Sophie Shi ... Pierre-Jean Corringer
    Conformational motions elicited by antagonists, partial agonists, and agonists in serotonin-gated ion channels 5-HT3AR progressively spread from the extracellular to the transmembrane domain.
    1. Structural Biology and Molecular Biophysics

    The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A

    Cristina Olivieri, Yingjie Wang ... Gianluigi Veglia
    The αC-β4 loop emerges as a hot spot for tuning allosteric cooperativity in the catalytic subunit of protein kinase A.
    1. Neuroscience

    Medial anterior prefrontal cortex stimulation downregulates implicit reactions to threats and prevents the return of fear

    Eugenio Manassero, Giulia Concina ... Benedetto Sacchetti
    Implicit defensive reactions to a learned threat-predictive cue and novel stimuli may be significantly downregulated through a repetitive transcranial magnetic stimulation procedure over the medial anterior prefrontal cortex in humans.