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    1. Neuroscience

    DIETS: a simple and sensitive assay to measure and control the intake of complex solid foods, like high-fat diets, in Drosophila

    Manikrao R. Thakare, Prerana Choudhary ... Gaurav Das
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology

    Cardiac neurons expressing a glucagon-like receptor mediate cardiac arrhythmia induced by high-fat diet in Drosophila

    Yunpo Zhao, Jianli Duan ... Zhe Han
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus

    Natalia E Ketaren, Fred D Mast ... John D Aitchison
    High-affinity nanobodies targeting the SARS-CoV-2 spike protein demonstrate sustained effectiveness against current and emerging variants, offering a promising avenue for treatment.
    1. Cell Biology
    2. Neuroscience

    Synapsin E-domain is essential for α-synuclein function

    Alexandra Stavsky, Leonardo A Parra-Rivas ... Daniel Gitler
    Alpha-synuclein binding to the synapsin E-domain is essential and sufficient for their cooperation in attenuating synaptic-vesicle trafficking and neurotransmission.
    Version of Record
    Short Report
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology

    Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases

    Benjamin R Duewell, Naomi E Wilson ... Scott D Hansen
    Single molecule reconstitution of PI3Kβ synergistic activation reveals mechanism for rapid PI(3,4,5)P3 production during immune cell signaling.
    1. Neuroscience

    A stochastic world model on gravity for stability inference

    Taicheng Huang, Jia Liu
    Empirical experiments and computational modeling reveal a stochastic world model on gravity for stability inference that represents gravity’s vertical direction as a Gaussian distribution.
    1. Structural Biology and Molecular Biophysics

    Some mechanistic underpinnings of molecular adaptations of SARS-COV-2 spike protein by integrating candidate adaptive polymorphisms with protein dynamics

    Nicholas James Ose, Paul Campitelli ... Sefika Banu Ozkan
    Insights from integrating evolutionary predictions and protein dynamics unveil how specific mutations in the SARS-CoV-2 spike protein epistatically interact in order to influence spike protein interaction with human cells, potentially altering the virus's infectivity and immune evasion capabilities.
    1. Neuroscience

    Drift of neural ensembles driven by slow fluctuations of intrinsic excitability

    Geoffroy Delamare, Yosif Zaki ... Claudia Clopath
    Internal neural variability can induce drift of memory ensembles through synaptic plasticity, allowing for encoding of temporal information.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Computational and Systems Biology
    2. Ecology

    Collaborative hunting in artificial agents with deep reinforcement learning

    Kazushi Tsutsui, Ryoya Tanaka ... Keisuke Fujii
    Collaborative hunting, characterized by the division of roles among predators, has emerged within a group of artificial agents through deep reinforcement learning.
    1. Genetics and Genomics

    Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4- and RMD9-dependent mechanisms

    Mohammad Alfatah, Jolyn Jia Jia Lim ... Frank Eisenhaber
    Revealing YBR238C's involvement in the TORC1–mitochondria feedback loop deepens our understanding of aging biology, emphasizing the TOMITO concept as a crucial mechanism in cellular aging regulation.
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