Browse our latest research

Page 394 of 1,810
    1. Physics of Living Systems

    The ability to sense the environment is heterogeneously distributed in cell populations

    Andrew Goetz, Hoda Akl, Purushottam Dixit
    Information transduction capacity of mammalian cells is high and varies substantially from cell to cell.
    1. Cell Biology

    CEP44 is required for maintaining centriole duplication and spindle integrity

    Donghui Zhang, Wenlu Wei ... Jianguo Chen
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Cell Biology

    Autoacetylation-mediated phase separation of TIP60 is critical for its functions

    Shraddha Dubey, Himanshu Gupta, Ashish Gupta
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Behavioral entrainment to rhythmic auditory stimulation can be modulated by tACS depending on the electrical stimulation field properties

    Yuranny Cabral-Calderin, Daniela van Hinsberg ... Molly J Henry
    Transcranial alternating current stimulation modulates behavioral entrainment to sounds.
    1. Neuroscience

    Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development

    Tian Yuan, Yifan Wang ... Zhuo Huang
    Unveiling NaV1.6's role in sensitizing Slack to quinidine disruption redefines KCNT1-related epilepsy treatment strategies.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Stable population structure in Europe since the Iron Age, despite high mobility

    Margaret L Antonio, Clemens L Weiß ... Jonathan K Pritchard
    Reconstructing human mobility patterns using historical period genomes illustrates how the Roman Empire’s military and economic activities catalyzed an era of transient movement against the backdrop of generations-long prehistoric migrations.
    1. Neuroscience

    Spatial transcriptomics and single-nucleus RNA sequencing reveal a transcriptomic atlas of adult human spinal cord

    Donghang Zhang, Yali Chen ... Cheng Zhou
    The molecular, cellular, and spatial heterogeneity of adult human spinal cord serve as an important resource to explore the mechanisms underlying spinal cord physiology and diseases.
    1. Genetics and Genomics

    Targeting sex determination to suppress mosquito populations

    Ming Li, Nikolay P Kandul ... Omar S Akbari
    Genetic analyses and mathematical modeling reveal that disrupting genes essential for sex determination and fertility in Aedes aegypti leads to the production of sterile males, effectively suppressing mosquito populations.
    1. Structural Biology and Molecular Biophysics

    Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM

    Cathrine Bergh, Urška Rovšnik ... Erik Lindahl
    A combination of molecular dynamics simulations and electron cryomicroscopy characterizes interactions of a pentameric ligand-gated ion channel with 25 lipid molecules, specifically in a functional state in which they were not previously observed.
    1. Genetics and Genomics
    2. Neuroscience

    Orai-mediated calcium entry determines activity of central dopaminergic neurons by regulation of gene expression

    Rishav Mitra, Shlesha Richhariya, Gaiti Hasan
    Expression of the appropriate repertoire of membrane channels, essential for activity of flight-promoting central dopaminergic neurons of Drosophila, requires store-operated Ca2+ entry during late pupal development and early adults.