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Locally delivered small-molecule sclerostin inhibitors are able to promote local osteogenesis in vitro and in clinically relevant in vivo models by simultaneously activating the canonical Wnt and BMP signaling pathways.

An in-depth exploratory analysis of the evolutionary and epidemiological dynamics of SARS-CoV-2 in Mexico during the first year of the epidemic provides an overview of different virus dynamics between the developing and developed world (represented by the USA and Mexico).

CD31 plays a pivotal role in neutrophil migration to inflamed sites by localizing to the uropod and promoting effective actin/integrin polarization and detachment, shedding light on the molecular mechanisms underlying extravasation and inflammation response.

From middle childhood to early adulthood, the preference to engage with novel choice options remained consistent, but aversion to reward uncertainty increased.

Distinct and direct functions of the RNA binding protein SAM68 regulate integrin signaling and focal adhesion dynamics that condition basement membrane deposition and angiogenic behavior of endothelial cells.

The representation of the retina in early visual cortex shows that human brains have diverse functional organizations, raising questions about developmental mechanisms for visual map formation and how reliably these can be described by average templates.

The novel role of Adgrf1 in the progression of fatty liver was revealed and targeting Adgrf1 is a promising therapeutic strategy for treating NAFLD patients.

In vivo modeling of neoantigen-restricted heterogeneity shows that clonal expression of neoantigens enhances anti-tumor T cell responses by increasing the stimulatory capacity of dendritic cells in the lymph node.

Sound cues that were associated with memories during wake elicit memory reactivations when replayed to human participants during rapid eye movement sleep, those memory reactivations are identifiable by machine learning models that directly relate electroencephalography patterns of wake and sleep.