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    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Investigating the composition and recruitment of the mycobacterial ImuA′–ImuB–DnaE2 mutasome

    Sophia Gessner, Zela Alexandria-Mae Martin ... Digby F Warner
    The interaction of ImuB with the β sliding clamp is essential for induced mutagenesis in mycobacteria and could be a novel target for new anti-tuberculosis drugs designed to inhibit the emergence of genetic resistance.
    1. Neuroscience

    Analogue signaling of somatodendritic synaptic activity to axon enhances GABA release in young cerebellar molecular layer interneurons

    Federico Trigo, Shin-ya Kawaguchi
    In cerebellar interneurons, somatodendritic subthreshold synaptic activity travels down the axon and augments AP-dependent GABA release by a modulation of the intermediate states of voltage-dependent Ca++ channels in the presynaptic boutons.
    1. Plant Biology

    The AUX1-AFB1-CNGC14 module establishes a longitudinal root surface pH profile

    Nelson BC Serre, Daša Wernerová ... Matyáš Fendrych
    Plant roots can rapidly change the acidity of their cell walls and the root-soil interface to efficiently navigate in the soil environment.
    1. Neuroscience

    Functional and microstructural plasticity following social and interoceptive mental training

    Sofie Louise Valk, Philipp Kanske ... Tania Singer
    Training attention-mindfulness, emotion-motivational, and social cognitive skills over the course of 3 months alters brain functional and microstructural organization as a function of training content.
    1. Cell Biology

    Hormone replacement therapy for postmenopausal atherosclerosis is offset by late age iron deposition

    Tianze Xu, Jing Cai ... Kuanyu Li
    Post-menopausal women with atherosclerosis need to take the correct timing for hormone replacement therapy.
    1. Epidemiology and Global Health

    Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: A cohort study using OpenSAFELY-TPP

    Agnieszka Lemanska, Colm Andrews ... Alex J Walker
    COVID-19 negatively affected pancreatic cancer care by reducing surgical resections and pre-diagnostic testing with BMI and HbA1c, and it also negatively affected the quality of data for research.
    1. Neuroscience

    Object representation in a gravitational reference frame

    Alexandriya MX Emonds, Ramanujan Srinath ... Charles E Connor
    Neural recordings in monkey IT show that the primate visual system transforms object representations into a reference frame aligned with gravity and independent of how the head and eyes are tilted.
    1. Developmental Biology

    Comparative single-cell profiling reveals distinct cardiac resident macrophages essential for zebrafish heart regeneration

    Ke-Hsuan Wei, I-Ting Lin ... Shih-Lei (Ben) Lai
    An extensive characterization of inflammatory cell dynamics, function, and potential interaction during zebrafish cardiac repair identified specific resident macrophage subsets function in debris clearance, inflammatory resolution, and extracellular matrix remodeling, indispensable for successful heart regeneration.
    1. Neuroscience

    Neuronal glutamate transporters control reciprocal inhibition and gain modulation in D1 medium spiny neurons

    Maurice A Petroccione, Lianna Y D'Brant ... Annalisa Scimemi
    The neuronal glutamate transporter EAAC1 limits excitation and lateral inhibition between D1-MSNs, which are important for the execution of slow-switching flexible behaviors.
    1. Neuroscience

    State-dependent coupling of hippocampal oscillations

    Brijesh Modi, Matteo Guardamagna ... Francesco P Battaglia
    A novel analytical framework for investigation of simultaneously occurring brain oscillations (from either single or multiple brain areas) and how it modulates the underlying neuronal population during sleep and wakefulness (or other behavioral tasks).